Publication: Surface roughness modification of bone tissue engineering scaffolds by electrochemical etching : optimization and quantitative characterization
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2010-06
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2011-10-01
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Abstract
Since surface roughness is known as an important property that determines and controls cell attachment and proliferation on the surfaces of porous TE scaffolds, a more controlled and homogeneous surface is required. In this study, two surface roughness modification procedures were proposed for Ti6Al4V scaffolds in order to achieve this aim: chemical etching followed by electrochemical polishing. This study dealt with the in depth characterization of the effect of the surface roughness modification on the morphological and mechanical properties of the porous Ti6Al4V scaffolds and on their roughness. In this way, feedback could be provided for optimization or fine-tuning of the surface roughness modification procedures. During electrochemical polishing, the current was maintained constant, thus depending on the scaffold design a different current density was applied. The role of the current density was found to be important for the changes in morphological, mechanical and roughness properties. Therefore, controlling this parameter, and hence also the reduction in morphological, mechanical and roughness properties, the surface roughness modification procedures will be more controlled and designing and producing customized porous Ti6Al4V scaffolds will be feasible. Additionally, in this study, initial characterization of the morphological and mechanical properties of two designs of porous PCL scaffolds was carried out and the effect of two different surface roughness modification procedures was qualitatively assessed, namely immersion for 96 hours in NaOH or in KOH.
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Materiales porosos, IngenierÃa biomédica