González Pérez, MarinaGómez Bombarelli, RafaelPérez Prior, María TeresaArenas Valgañón, JorgeGarcía Santos, María PilarCalle, EmilioCasado, Julio2021-02-082021-02-082014-09-15Chemical Research in Toxicology, (2014), 27(10), pp.: 1853–1859.0893-228Xhttps://hdl.handle.net/10016/31876The chemical reactivity of styrene-7,8-oxide (SO), an alkylating agent with high affinity for the guanine-N7 position and a probable carcinogen for humans, with 4-(p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to those of DNA bases, was investigated kinetically in water/dioxane media. UV-vis spectrophotometry and ultrafast liquid chromatography were used to monitor the reactions involved...6eng© 2014 American Chemical Society.AlcoholsAdductsKinetic parametersHydrolysisPost-translational modificationresearch articleMaterialeshttps://doi.org/10.1021/tx5002892open access1853101859CHEMICAL RESEARCH IN TOXICOLOGY27AR/0000016394