Gómez Talavera, SandraFernández Jiménez, RodrigoFuster, ValentínNothnagel, Nils DennisKouwenhoven, MarcClemence, MatthewGarcía Lunar, InésGómez Rubín, María C.Navarro, FelipePérez Asenjo, BraulioFernández Friera, LeticiaCalero, María J.Orejas, MiguelCabrera, José A.Desco Menéndez, ManuelPizarro, GonzaloIbáñez, BorjaSánchez González, Javier2022-03-212022-03-212021-09Gómez-Talavera, S., Fernandez-Jimenez, R., Fuster, V., Nothnagel, N. D., Kouwenhoven, M., Clemence, M., García-Lunar, I., Gómez-Rubín, M. C., Navarro, F., Pérez-Asenjo, B., Fernández-Friera, L., Calero, M. J., Orejas, M., Cabrera, J. A., Desco, M., Pizarro, G., Ibáñez, B., & Sánchez-González, J. (2021). Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences. In JACC: Cardiovascular Imaging (Vol. 14, Issue 9, pp. 1742–1754). Elsevier BV.1936-878Xhttps://hdl.handle.net/10016/34424Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. Background: CMR is the reference tool for cardiac imaging but is time-consuming. Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences. Results: Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE. Conclusions: ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in less than 1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort. (J Am Coll Cardiol Img 2021;14:1742–1754)12eng© 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.Atribución-NoComercial-SinDerivadas 3.0 EspañaAccelerated protocolContrast mediaGadoliniumHeartMagnetic resonanceMyocardiumresearch articleBiología y Biomedicinahttps://doi.org/10.1016/j.jcmg.2021.02.031open access174291754JACC: Cardiovascular Imaging14AR/0000028883