García Vázquez, VerónicaCalvo, Felipe ALedesma Carbayo, María JesúsVicente Solé, ClaudioCalvo Haro, José AntonioDesco Menéndez, ManuelPascau González-Garzón, Javier2021-02-122021-02-122020-01-10García-Vázquez V, Calvo FA, Ledesma-Carbayo MJ, Sole CV, Calvo-Haro J, Desco M, et al. (2020) Intraoperative computed tomography imaging for dose calculation in intraoperative electron radiation therapy: Initial clinical observations. PLoS ONE 15(1): e02271551932-6203https://hdl.handle.net/10016/31915In intraoperative electron radiation therapy (IOERT) the energy of the electron beam is selected under the conventional assumption of water-equivalent tissues at the applicator end. However, the treatment field can deviate from the theoretic flat irradiation surface, thus altering dose profiles. This patient-based study explored the feasibility of acquiring intraoperative computed tomography (CT) studies for calculating three-dimensional dose distributions with two factors not included in the conventional assumption, namely the air gap from the applicator end to the irradiation surface and tissue heterogeneity. In addition, dose distributions under the conventional assumption and from preoperative CT studies (both also updated with intraoperative data) were calculated to explore whether there are other alternatives to intraoperative CT studies that can provide similar dose distributions. The IOERT protocol was modified to incorporate the acquisition of intraoperative CT studies before radiation delivery in six patients.12eng© 2020 García-Vázquez et al.Atribución 3.0 EspañaComputed axial tomographyTissue distributionSurgical and invasive medical proceduresBreast cancerRadiation therapyCancer treatmentImage processingSurgical oncologyresearch articleBiología y Biomedicinahttps://doi.org/10.1371/journal.pone.0227155open access1(e0227155)PLoS One15AR/0000024190