Marín Rubio, José L.Arriba Pérez, María del Carmen deCobos Fernández, María A.González Sánchez, LauraOrs, InmaculadaSastre, IsabelFernández Piqueras, JoséVilla Morales, María2023-11-062023-11-062016-08-18Marín-Rubio, J. L., Arriba, M., Cobos-Fernández, M. Á., González-Sánchez, L., Ors, I., Sastre, I., Fernández‐Piqueras, J., & Villa‐Morales, M. (2016). Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma. Oncotarget, 7(38), 61485-61499.1949-2553https://hdl.handle.net/10016/38762In the present work, we show that T-cell lymphoblastic lymphoma cells exhibit a reduction of FADD availability in the cytoplasm, which may contribute to impaired apoptosis. In addition, we observe a reduction of FADD phosphorylation that inversely correlates with the proliferation capacity and tumor aggressiveness. The resultant balance between FADD-dependent apoptotic and non-apoptotic abilities may define the outcome of the tumor. Thus, we propose that FADD expression and phosphorylation can be reliable biomarkers with prognostic value for T-LBL stratification.15eng© The Authors, 2016.Atribución 3.0 EspañaT-cell lymphoblastic lymphomaFas-associated death domain protein (FADD)Expression and phosphorylationTumor aggressivenessPrognostic markerresearch articleBiología y BiomedicinaElectrónicaMedicinahttps://doi.org/10.18632/oncotarget.11370open access614853861499Oncotarget7AR/0000018454