López Bonilla, Luis FranciscoCarretero Cerrajero, ManuelTerragni, Filippo2020-12-172021-11-182020-11-18Bonilla, L. L., Carretero, M., & Terragni, F. (2020). Integrodifference master equation describing actively growing blood vessels in angiogenesis, International Journal of Nonlinear Sciences and Numerical Simulation, 21(7-8), 705-7131565-1339https://hdl.handle.net/10016/31633We study a system of particles in a two-dimensional geometry that move according to a reinforced random walk with transition probabilities dependent on the solutions of reaction-diffusion equations (RDEs) for the underlying fields. A birth process and a history-dependent killing process are also considered. This system models tumor-induced angiogenesis, the process of formation of blood vessels induced by a growth factor (GF) released by a tumor. Particles represent vessel tip cells, whose trajectories constitute the growing vessel network. New vessels appear and may fuse with existing ones during their evolution. Thus, the system is described by tracking the density of active tips, calculated as an ensemble average over many realizations of the stochastic process. Such density satisfies a novel discrete master equation with source and sink terms. The sink term is proportional to a space-dependent and suitably fitted killing coefficient. Results are illustrated studying two influential angiogenesis models.eng© 2020 Walter de Gruyter GmbH, Berlin/Bostonresearch articleMatemáticashttps://doi.org/10.1515/ijnsns-2019-0094open access7057-8713International Journal of Nonlinear Sciences and Numerical Simulation21AR/0000026347