Barrejón Moreno, DanielMartínez Olmos, PabloArtés Rodríguez, Antonio2022-06-062022-06-062022-06IEEE Journal of biomedical and health informatics, 26(6), Jun. 2022, Pp. 2737-27452168-21942168-2208 (online)https://hdl.handle.net/10016/35008Medical data sets are usually corrupted by noise and missing data. These missing patterns are commonly assumed to be completely random, but in medical scenarios, the reality is that these patterns occur in bursts due to sensors that are off for some time or data collected in a misaligned uneven fashion, among other causes. This paper proposes to model medical data records with heterogeneous data types and bursty missing data using sequential variational autoencoders (VAEs). In particular, we propose a new methodology, the Shi-VAE, which extends the capabilities of VAEs to sequential streams of data with missing observations. We compare our model against state-of-theart solutions in an intensive care unit database (ICU) and a dataset of passive human monitoring. Furthermore, we find that standard error metrics such as RMSE are not conclusive enough to assess temporal models and include in our analysis the cross-correlation between the ground truth nd the imputed signal. We show that Shi-VAE achieves the best performance in terms of using both metrics, with lower computational complexity than the GP-VAE model, which is the state-of-the-art method for medical records.9eng© 2021 IEEE.Deep learningVariational autoencodersMissing dataHeterogeneousSequential dataresearch articleBiología y BiomedicinaTelecomunicacioneshttps://doi.org/10.1109/JBHI.2021.3123839open access273762745IEEE Journal of Biomedical and Health Informatics26AR/0000028561