RT Journal Article
T1 Response to deep brain stimulation in three brain targets with implications in mental disorders: a PET study in rats
A1 Casquero-Veiga, Marta
A1 Hadar, Ravit
A1 Pascau González-Garzón, Javier
A1 Winter, Christine
A1 Desco Menéndez, Manuel
A1 Soto Montenegro, Mª Luisa
AB Objective: To investigate metabolic changes in brain networks by deep brain stimulation (DBS) of the medial prefrontal cortex (mPFC), nucleus accumbens (NAcc) and dorsomedial thalamus (DM) using positron emission tomography (PET) in naïve rats. Methods: 43 male Wistar rats underwent stereotactic surgery and concentric bipolar platinum-iridium electrodes were bilaterally implanted into one of the three brain sites. [18F]-fluoro-2-deoxy-glucose-PET (18FDG-PET) and computed tomography (CT) scans were performed at the 7th (without DBS) and 9th day (with DBS) after surgery. Stimulation period matched tracer uptake period. Images were acquired with a small-animal PET-CT scanner. Differences in glucose uptake between groups were assessed with Statistical Parametric Mapping. Results: DBS induced site-specific metabolic changes, although a common increased metabolic activity in the piriform cortex was found for the three brain targets. mPFC-DBS increased metabolic activity in the striatum, temporal and amygdala, and reduced it in the cerebellum, brainstem (BS) and periaqueductal gray matter (PAG). NAcc-DBS increased metabolic activity in the subiculum and olfactory bulb, and decreased it in the BS, PAG, septum and hypothalamus. DM-DBS increased metabolic activity in the striatum, NAcc and thalamus and decreased it in the temporal and cingulate cortex. Conclusions: DBS induced significant changes in 18FDG uptake in brain regions associated with the basal ganglia-thalamo-cortical circuitry. Stimulation of mPFC, NAcc and DM induced different patterns of 18FDG uptake despite interacting with the same circuitries. This may have important implications to DBS research suggesting individualized target selection according to specific neural modulatory requirements.
PB PLOS
SN 1932-6203
YR 2016
FD 2016-12-29
LK https://hdl.handle.net/10016/38796
UL https://hdl.handle.net/10016/38796
LA eng
NO This research was conducted under the EraNet Neuron framework (DBS_F20rat) and supported by the Federal Ministry of Education and Research, Germany (BMBF 01EW1103), the Ministry of Economy and Competitiveness ISCIII-FIS grants (PI14/00860, CPII/00005) co-financed by ERDF (FEDER) Funds from the European Commission, "A way of making Europe", Fundación Mapfre and Comunidad de Madrid (BRADE S2013/ICE-2958).
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RD 17 jul. 2024