RT Journal Article
T1 Highly integrated autonomous lab-on-a-chip device for on-line and in situ determination of environmental chemical parameters
A1 Martínez Cisneros, Cynthia Susana
A1 Da Rocha, Zaira
A1 Seabra, Antonio
A1 Alonso Chamarro, Julián
A1 Valdés, Francisco
AB The successful integration of sample pretreatment stages, sensors, actuators and electronics in microfluidic devices enables the attainment of complete micro total analysis systems, also known as lab-on-a-chip devices. In this work, we present a novel monolithic autonomous microanalyzer that integrates microfluidics, electronics, a highly sensitive photometric detection system and a sample pretreatment stage consisting on an embedded microcolumn, all in the same device, for on-line determination of relevant environmental parameters. The microcolumn can be filled/emptied with any resin or powder substrate whenever required, paving the way for its application to several analytical processes: separation, pre-concentration or ionic-exchange. To promote its autonomous operation, avoiding issues caused by bubbles in photometric detection systems, an efficient monolithic bubble removal structure was also integrated. To demonstrate its feasibility, the microanalyzer was successfully used to determine nitrate and nitrite in continuous flow conditions, providing real time and continuous information.
PB Royal Society of Chemistry
SN 1473-0197
YR 2018
FD 2018-07-01
LK https://hdl.handle.net/10016/39083
UL https://hdl.handle.net/10016/39083
LA eng
NO Authors would like to acknowledge the Spanish MINECO and the Catalonia Government for their financial support through the projects CTQ2017-85011R and 2017 SGR220, respectively. Partial financial support from Met-Mex Pefioles is also acknowledged.
DS e-Archivo
RD 1 sept. 2024