RT Journal Article
T1 Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences
A1 Gómez Talavera, Sandra
A1 Fernández Jiménez, Rodrigo
A1 Fuster, Valentín
A1 Nothnagel, Nils Dennis
A1 Kouwenhoven, Marc
A1 Clemence, Matthew
A1 García Lunar, Inés
A1 Gómez Rubín, María C.
A1 Navarro, Felipe
A1 Pérez Asenjo, Braulio
A1 Fernández Friera, Leticia
A1 Calero, María J.
A1 Orejas, Miguel
A1 Cabrera, José A.
A1 Desco Menéndez, Manuel
A1 Pizarro, Gonzalo
A1 Ibáñez, Borja
A1 Sánchez González, Javier
AB Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. Background: CMR is the reference tool for cardiac imaging but is time-consuming. Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences. Results: Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE. Conclusions: ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in less than 1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort. (J Am Coll Cardiol Img 2021;14:1742–1754)
PB ELSEVIER BV
SN 1936-878X
YR 2021
FD 2021-09
LK https://hdl.handle.net/10016/34424
UL https://hdl.handle.net/10016/34424
LA eng
NO Funding included Instituto de Salud Carlos III (ISCIII) and theEuropean Regional Development Fund (ERDF) Grants DTS17/00136 toDr. Ibáñez and PI19/01704 to Dr. Fernandez-Jimenez; Spanish Societyof Cardiology Translational Research Grant 2016 to Dr. Ibáñez;European Research Council ERC-CoG 819775-MATRIX to Dr. Ibáñez;Comunidad de Madrid S2017/BMD-3867-RENIM-CM to Drs. Descoand Ibáñez; and Ministerio de Ciencia e Innovación (MICINN)RETOS2019-107332RB-I00 to Dr. Ibáñez. Dr. Fernandez-Jimenez received funding from the European Union Horizon 2020 research and innovation programme under Marie Sklodowska-Curie HrantAgreement No. 707642. The CNIC is supported by the ISCIII, theMICINN, and the Pro CNIC Foundation. Drs. Fernandez-Jimenez,Nothnagel, Fuster, Ibáñez, and Javier Sánchez-González are inventorsof a joint patent (Philips/CNIC) for the new cine imagingmethod here described and validated/protected under the IP#2014P00960EP. Drs. Nothnagel, Kouwenhoven, Clemence, andJavier Sánchez-González are Philips employees. All other authorshave reported that they have no relationships relevant to the contentsof this paper to disclose.
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