RT Journal Article
T1 Qualitative disorder measurements from backscattering spectra through an optical fiber
A1 Fernández Sánchez, Rafael
A1 Marcos Vidal, Asier
A1 Gallego, S.
A1 Beléndez, A.
A1 Desco Menéndez, Manuel
A1 Ripoll Lorenzo, Jorge
AB In the processes related to the development of cancer, there are different genetic and epigenetic events involved that result in structural changes of the affected cells. In the early stages of the disease, these changes occur at the nanoscale, remaining undetectable by conventional light microscopy, due to diffraction-limited resolution (~250 - 550 nm). In this sense, a technique termed partial wave spectroscopy (PWS) allows the detection of these nanostructural changes by measuring a statistical parameter called disorder strength (Ld). PWS uses a combination of a tunable filter and a camera to acquire the backscattering spectra for each pixel on the image. In this paper, we study and validate the possibility of obtaining a qualitative measurement of the disorder using the spectrum of the averaged spatial information. Instead of using spatial information and measuring sequentially spectral ranges, we measure the backscattered signal gathered by an optical fiber by means of a spectrograph. This will allow this method to be applied in systems where it is not possible to acquire a complete high resolution image for many spectral bands, while significantly enhancing speed.
PB OSA
SN 2156-7085
YR 2020
FD 2020-10-01
LK https://hdl.handle.net/10016/37940
UL https://hdl.handle.net/10016/37940
LA eng
NO Horizon 2020 Framework Programme (801347-SENSITIVE); Ministerio de Economía y Competitividad (FIS2016-77892-R); Conselleria d'Educació, Investigació, Cultura i Esport (APOSTD/2018/A/084); Comunidad de Madrid (S2017/BMD-3867 RENIM-CM); Ministerio de Ciencia, Innovación y Universidades (SEV-2015-0505).
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RD 3 jun. 2024