RT Conference Proceedings T1 Validation of a restrospective respiratory gating method for small-animal CT scanners A1 Chavarrías, Cristina A1 Vaquero López, Juan José A1 Sisniega, Alejandro A1 Rodríguez Ruano, Alexia A1 Soto Montenegro, Mª Luisa A1 Desco Menéndez, Manuel AB We propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections ofsmall-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, subtraction of their average image from each individual frame produces a set of differenceimages. The respiratory signals were extracted by analyzing the shape of the histogram of these difference images: we calculated the first four central and non-central moments. However, only odd-order moments produced the desired breathing signal, as the even-order moments lackedinformation about the phase. Each of these curves was compared to a reference signal recorded by means of a pneumatic pillow. Given the similar correlation coefficients yielded by all of them, we selected themean to implement our retrospective protocol. Respiratory phase bins were separated, reconstructed independently and included in a dynamic sequence, suitable for cine playback. We validated our method in 5 adult rat studies by comparing profiles drawn across the diaphragm dome, with and without retrospective respiratory gating. Results showed a sharper transition in the gated reconstruction, with an average slopeimprovement of 60.7%. PB IEEE SN 978-1-4244-2714-7 SN 1082-3654 YR 2008 FD 2008-10 LK https://hdl.handle.net/10016/12200 UL https://hdl.handle.net/10016/12200 LA eng NO Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 October 2008 NO This project was supported by the CENITProgramme (Ministerio de Industria), CIBER CB07/09/0031 and RETICRECAVA (Ministerio de Sanidad y Consumo), and TEC2007-64731 TCM(Ministerio de Educaci6n y Ciencia). DS e-Archivo RD 1 may. 2024