RT Conference Proceedings
T1 FDOT reconstruction and setting optimization using singular value analysis with automatic thresholding
A1 Chamorro Servent, Judit
A1 Aguirre, Juan
A1 Ripoll Lorenzo, Jorge
A1 Vaquero López, Juan José
A1 Desco Menéndez, Manuel
AB Fluorescence Enhanced Diffuse Optical Tomography (FDOT) retrieves 3D distributions of fluorophore concentration in small animals, non-invasively and in vivo. The FDOT problem can be formulated as a system of equations, d=Wf, where W is a weight matrix that couples the measurements (d) to the unknown spatial distribution (f) of thefluorophore concentration (forward problem). The Singular Value Decomposition (SVD) of W has been previously employed to solve the inverse problem (image reconstruction) and to study the imaging performance of FDOT.To achieve good image quality it is necessary to determine the number of useful singular values to retain. We use an automatic method that analytically calculates a threshold to select thesignificant singular values for SVD reconstruction of FDOT experiments previously validity in our laboratory.Afterwards, this work appraises the effect of different settings of the acquisition parameters (distribution of mesh points, density of sources and detectors) of a parallel-plate noncontactFDOT, in order to achieve the best possible imaging performance, i.e., minimum number of singular values of W, maximum information content in acquired measurements and minimum computational cost.We conclude that the use of a mesh with lower density in the direction perpendicular to the plates achieves better performance than the usual isotropic mesh points distribution.Any increase in the number of mesh points, sources and detectors at distances shorter than the photon mean free path leads to slight improvements in image quality while increasingcomputational burden.
PB IEEE
SN 978-1-4244-3961-4
SN 1082-3654
YR 2009
FD 2009-10
LK https://hdl.handle.net/10016/12197
UL https://hdl.handle.net/10016/12197
LA eng
NO 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC), Orlando, Florida, 25-31 October 2009
NO This work is supported in part by Fundacion Caja Navarra (#12180), Ministerio de Ciencia e Innovacion (TEC2008-06715 and TEC2007-64731)and EU-FP7 project FMTXCT-201792.
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RD 4 may. 2024