Assessment of a New High-Performance Small-Animal X-Ray Tomograph

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dc.contributor.author Vaquero López, Juan José
dc.contributor.author Redondo, Santiago
dc.contributor.author Abella García, Mónica
dc.contributor.author Sisniega, Alejandro
dc.contributor.author Tapias, Gustavo
dc.contributor.author Montenegro, M. L. S.
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Lage Negro, Eduardo
dc.date.accessioned 2011-01-12T11:37:23Z
dc.date.available 2011-01-12T11:37:23Z
dc.date.issued 2008-06
dc.identifier.bibliographicCitation IEEE Transactions on Nuclear Science, 2008, vol. 55, n. 3, p. 898-905
dc.identifier.issn 0018-9499
dc.identifier.uri http://hdl.handle.net/10016/9956
dc.description.abstract We have developed a new X-ray cone-beam tomograph for in vivo small-animal imaging using a flat panel detector (CMOS technology with a microcolumnar CsI scintillator plate) and a microfocus X-ray source. The geometrical configuration was designed to achieve a spatial resolution of about 12 lpmm with a field of view appropriate for laboratory rodents. In order to achieve high performance with regard to per-animal screening time and cost, the acquisition software takes advantage of the highest frame rate of the detector and performs on-the-fly corrections on the detector raw data. These corrections include geometrical misalignments, sensor non-uniformities, and defective elements. The resulting image is then converted to attenuation values. We measured detector modulation transfer function (MTF), detector stability, system resolution, quality of the reconstructed tomographic images and radiated dose. The system resolution was measured following the standard test method ASTM E 1695 -95. For image quality evaluation, we assessed signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) as a function of the radiated dose. Dose studies for different imaging protocols were performed by introducing TLD dosimeters in representative organs of euthanized laboratory rats. Noise figure, measured as standard deviation, was 50 HU for a dose of 10 cGy. Effective dose with standard research protocols is below 200 mGy, confirming that the system is appropriate for in vivo imaging. Maximum spatial resolution achieved was better than 50 micron. Our experimental results obtained with image quality phantoms as well as with in-vivo studies show that the proposed configuration based on a CMOS flat panel detector and a small micro-focus X-ray tube leads to a compact design that provides good image quality and low radiated dose, and it could be used as an add-on for existing PET or SPECT scanners
dc.description.sponsorship IEEE Nuclear and Plasma Sciences Society
dc.format.mimetype application/octet-stream
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.subject.other X-ray
dc.title Assessment of a New High-Performance Small-Animal X-Ray Tomograph
dc.type article
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1109/TNS.2008.922814
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/TNS.2008.922814
dc.rights.accessRights openAccess
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 898
dc.identifier.publicationissue 3
dc.identifier.publicationlastpage 905
dc.identifier.publicationtitle IEEE Transactions on Nuclear Science
dc.identifier.publicationvolume 55
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