Resolution Uniformity and Sensitivity of the NIH ATLAS Small Animal PET Scanner: Comparison to Simulated LSO Scanners Without Depth-of-Interaction Capability

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dc.contributor.author Seidel, J.
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Green, M. V.
dc.date.accessioned 2010-10-05T10:55:37Z
dc.date.available 2010-10-05T10:55:37Z
dc.date.issued 2003-10
dc.identifier.bibliographicCitation IEEE Transactions on Nuclear Science, 2003, vol. 50, n. 5, p. 1347 - 1350
dc.identifier.issn 0018-9499
dc.identifier.uri http://hdl.handle.net/10016/9358
dc.description.abstract Positron emission tomography (PET) scanners designed to image animals the size of rats and mice should possess simultaneously high and uniform spatial resolution and high sensitivity. ATLAS (Advanced Technology Laboratory Animal Scanner), a 6.0 cm diameter effective transverse field-of-view (FOV), 2 cm axial FOV ring-type research scanner seeks these goals by surrounding the animal with eighteen 15 mm deep, LGSO (7 mm)/GSO (8 mm) phoswich detector modules. A Monte Carlo simulation was used to compare the variation of resolution across the FOV and the absolute central point source sensitivity (ACS) of ATLAS to similar systems comprised only of LSO arrays of different depths with no depth-of-interaction (DOI) capability. For ATLAS radial spatial resolution deteriorated by 27% from the center to 3 cm off-axis. Scanners comprised of 15 mm deep, 10 mm deep and 7 mm deep LSO crystals deteriorated by 100%, 51%, and 20%, respectively, over the same distance. Simulated ACS (absorbed energies ≥250 keV) for ATLAS was 2.0% and for the 15 mm, 10 mm deep and 7 mm deep LSO scanners 2.4%, 1.5%, and 0.9%, respectively. Radial resolution loss 3 cm off-axis and ACS measured for the actual ATLAS scanner were similar to the values obtained by simulation (27% resolution loss, 1.8% ACS). The phoswich design thus achieves good resolution uniformity over a 6 cm FOV while preserving sensitivity compared to equivalent non-DOI LSO scanners with a range of crystal depths.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.relation.isversionof http://hdl.handle.net/10016/12110
dc.rights © IEEE
dc.subject.other Monte Carlo methods
dc.subject.other Biological techniques
dc.title Resolution Uniformity and Sensitivity of the NIH ATLAS Small Animal PET Scanner: Comparison to Simulated LSO Scanners Without Depth-of-Interaction Capability
dc.type article
dc.type.review PeerReviewed
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1109/TNS.2003.817282
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/TNS.2003.817282
dc.rights.accessRights openAccess
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 1347
dc.identifier.publicationissue 5
dc.identifier.publicationlastpage 1350
dc.identifier.publicationtitle IEEE Transactions on Nuclear Science
dc.identifier.publicationvolume 50
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