Two mechanisms regulate directional cell growth in Arabidopsis lateral roots

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Show simple item record García González, Daniel 2022-04-01T17:33:57Z 2022-04-01T17:33:57Z 2019-01-01
dc.identifier.bibliographicCitation Goryakin, Y., Thiébaut, S. P., Cortaredona, S., Lerouge, M. A., Cecchini, M., Feigl, A. B., & Ventelou, B. (2020). Assessing the future medical cost burden for the European health systems under alternative exposure-to-risks scenarios. PLOS ONE, 15(9), p. e0238565
dc.identifier.issn 2050-084X
dc.description.abstract Morphogenesis in plants depends critically on directional (anisotropic) growth. This occurs principally perpendicular to the net orientation of cellulose microfibrils (CMFs), which is in turn controlled by cortical microtubules (CMTs). In young lateral roots of Arabidopsis thaliana, growth anisotropy also depends on RAB-A5c, a plant-specific small GTPase that specifies a membrane trafficking pathway to the geometric edges of cells. Here we investigate the functional relationship between structural anisotropy at faces and RAB-A5c activity at edges during lateral root development. We show that surprisingly, inhibition of RAB-A5c function is associated with increased CMT/CMF anisotropy. We present genetic, pharmacological, and modelling evidence that this increase in CMT/CMF anisotropy partially compensates for loss of an independent RAB-A5c-mediated mechanism that maintains anisotropic growth in meristematic cells. We show that RAB-A5c associates with CMTs at cell edges, indicating that CMTs act as an integration point for both mechanisms controlling cellular growth anisotropy in lateral roots
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights © 2020 Goryakin et al.
dc.rights Atribución-NoComercial 3.0 España
dc.title Two mechanisms regulate directional cell growth in Arabidopsis lateral roots
dc.type article
dc.rights.accessRights openAccess
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue e47988
dc.identifier.publicationlastpage 26
dc.identifier.publicationtitle eLife
dc.identifier.publicationvolume 8
dc.identifier.uxxi AR/0000024984
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