Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences

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dc.contributor.author Gómez Talavera, Sandra
dc.contributor.author Fernández Jiménez, Rodrigo
dc.contributor.author Fuster, Valentín
dc.contributor.author Nothnagel, Nils Dennis
dc.contributor.author Kouwenhoven, Marc
dc.contributor.author Clemence, Matthew
dc.contributor.author García Lunar, Inés
dc.contributor.author Gómez Rubín, María C.
dc.contributor.author Navarro, Felipe
dc.contributor.author Pérez Asenjo, Braulio
dc.contributor.author Fernández Friera, Leticia
dc.contributor.author Calero, María J.
dc.contributor.author Orejas, Miguel
dc.contributor.author Cabrera, José A.
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Pizarro, Gonzalo
dc.contributor.author Ibáñez, Borja
dc.contributor.author Sánchez González, Javier
dc.date.accessioned 2022-03-21T09:18:44Z
dc.date.available 2022-03-21T09:18:44Z
dc.date.issued 2021-09
dc.identifier.bibliographicCitation Gómez-Talavera, S., Fernandez-Jimenez, R., Fuster, V., Nothnagel, N. D., Kouwenhoven, M., Clemence, M., García-Lunar, I., Gómez-Rubín, M. C., Navarro, F., Pérez-Asenjo, B., Fernández-Friera, L., Calero, M. J., Orejas, M., Cabrera, J. A., Desco, M., Pizarro, G., Ibáñez, B., & Sánchez-González, J. (2021). Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences. In JACC: Cardiovascular Imaging (Vol. 14, Issue 9, pp. 1742–1754). Elsevier BV.
dc.identifier.issn 1936-878X
dc.identifier.uri http://hdl.handle.net/10016/34424
dc.description.abstract Objectives: This study sought to clinically validate a novel 3-dimensional (3D) ultrafast cardiac magnetic resonance (CMR) protocol including cine (anatomy and function) and late gadolinium enhancement (LGE), each in a single breath-hold. Background: CMR is the reference tool for cardiac imaging but is time-consuming. Methods: A protocol comprising isotropic 3D cine (Enhanced sensitivity encoding [SENSE] by Static Outer volume Subtraction [ESSOS]) and isotropic 3D LGE sequences was compared with a standard cine+LGE protocol in a prospective study of 107 patients (age 58 ± 11 years; 24% female). Left ventricular (LV) mass, volumes, and LV and right ventricular (RV) ejection fraction (LVEF, RVEF) were assessed by 3D ESSOS and 2D cine CMR. LGE (% LV) was assessed using 3D and 2D sequences. Results: Three-dimensional and LGE acquisitions lasted 24 and 22 s, respectively. Three-dimensional and LGE images were of good quality and allowed quantification in all cases. Mean LVEF by 3D and 2D CMR were 51 ± 12% and 52 ± 12%, respectively, with excellent intermethod agreement (intraclass correlation coefficient [ICC]: 0.96; 95% confidence interval [CI]: 0.94 to 0.97) and insignificant bias. Mean RVEF 3D and 2D CMR were 60.4 ± 5.4% and 59.7 ± 5.2%, respectively, with acceptable intermethod agreement (ICC: 0.73; 95% CI: 0.63 to 0.81) and insignificant bias. Both 2D and 3D LGE showed excellent agreement, and intraobserver and interobserver agreement were excellent for 3D LGE. Conclusions: ESSOS single breath-hold 3D CMR allows accurate assessment of heart anatomy and function. Combining ESSOS with 3D LGE allows complete cardiac examination in less than 1 min of acquisition time. This protocol expands the indication for CMR, reduces costs, and increases patient comfort. (J Am Coll Cardiol Img 2021;14:1742–1754)
dc.description.sponsorship Funding included Instituto de Salud Carlos III (ISCIII) and the European Regional Development Fund (ERDF) Grants DTS17/00136 to Dr. Ibáñez and PI19/01704 to Dr. Fernandez-Jimenez; Spanish Society of Cardiology Translational Research Grant 2016 to Dr. Ibáñez; European Research Council ERC-CoG 819775-MATRIX to Dr. Ibáñez; Comunidad de Madrid S2017/BMD-3867-RENIM-CM to Drs. Desco and Ibáñez; and Ministerio de Ciencia e Innovación (MICINN) RETOS2019-107332RB-I00 to Dr. Ibáñez. Dr. Fernandez-Jimenez received funding from the European Union Horizon 2020 research and innovation programme under Marie Sklodowska-Curie Hrant Agreement No. 707642. The CNIC is supported by the ISCIII, the MICINN, and the Pro CNIC Foundation. Drs. Fernandez-Jimenez, Nothnagel, Fuster, Ibáñez, and Javier Sánchez-González are inventors of a joint patent (Philips/CNIC) for the new cine imaging method here described and validated/protected under the IP #2014P00960EP. Drs. Nothnagel, Kouwenhoven, Clemence, and Javier Sánchez-González are Philips employees. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
dc.format.extent 12
dc.language.iso eng
dc.publisher ELSEVIER BV
dc.rights © 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Accelerated protocol
dc.subject.other Contrast media
dc.subject.other Gadolinium
dc.subject.other Heart
dc.subject.other Magnetic resonance
dc.subject.other Myocardium
dc.title Clinical Validation of a 3-Dimensional Ultrafast Cardiac Magnetic Resonance Protocol Including Single Breath-Hold 3-Dimensional Sequences
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi https://doi.org/10.1016/j.jcmg.2021.02.031
dc.rights.accessRights openAccess
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/707642
dc.relation.projectID Universidad Carlos III de Madrid. DTS17/00136
dc.relation.projectID Universidad Carlos III de Madrid. PI19/01704
dc.relation.projectID info:eu-repo/grantAgreement/EC/H2020/ERC-CoG 819775-MATRIX
dc.relation.projectID Comunidad de Madrid. S2017/BMD-3867-RENIM-CM
dc.relation.projectID Gobierno de España. RETOS2019-107332RB-I00
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1742
dc.identifier.publicationissue 9
dc.identifier.publicationlastpage 1754
dc.identifier.publicationtitle JACC: Cardiovascular Imaging
dc.identifier.publicationvolume 14
dc.identifier.uxxi AR/0000028883
dc.contributor.funder Comunidad de Madrid
dc.contributor.funder European Commission
dc.contributor.funder Ministerio de Ciencia e Innovación (España)
dc.contributor.funder Universidad Carlos III de Madrid
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