Stimulating the nucleus accumbens in obesity: a positron emission tomography study after deep brain stimulation in a rodent model

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Show simple item record Casquero-Veiga, Marta García García, David Pascau González-Garzón, Javier Desco Menéndez, Manuel Soto Montenegro, Mª Luisa 2021-06-08T08:51:54Z 2021-06-08T08:51:54Z 2018-09-27
dc.identifier.bibliographicCitation Casquero-Veiga, et al. Stimulating the nucleus accumbens in obesity: a positron emission tomography study after deep brain stimulation in a rodent model. In: PLoS ONE 13(9): e0204740, Sept. 2018, 14 pp.
dc.identifier.issn 1932-6203
dc.description.abstract Purpose: The nucleus accumbens (NAcc) has been suggested as a possible target for deep brain stimulation (DBS) in the treatment of obesity. Our hypothesis was that NAcc-DBS would modulate brain regions related to reward and food intake regulation, consequently reducing the food intake and, finally, the weight gain. Therefore, we examined changes in brain glucose metabolism, weight gain and food intake after NAcc-DBS in a rat model of obesity. Procedures: Electrodes were bilaterally implanted in 2 groups of obese Zucker rats targeting the NAcc. One group received stimulation one hour daily during 15 days, while the other remained as control. Weight and daily consumption of food and water were everyday registered the days of stimulation, and twice per week during the following month. Positron emission tomography (PET) studies with 2-deoxy-2-[F-18] fluoro-D-glucose (FDG) were performed 1 day after the end of DBS. PET data was assessed by statistical parametric mapping (SPM12) software and region of interest (ROI) analyses. Results: NAcc-DBS lead to increased metabolism in the cingulate-retrosplenial-parietal association cortices, and decreased metabolism in the NAcc, thalamic and pretectal nuclei. Furthermore, ROIs analyses confirmed these results by showing a significant striatal and thalamic hypometabolism, and a cortical hypermetabolic region. However, NAcc-DBS did not induce a decrease in either weight gain or food intake. Conclusions: NAcc-DBS led to changes in the metabolism of regions associated with cognitive and reward systems, whose impairment has been described in obesity.
dc.description.sponsorship This research was supported by the Ministry of Economy and Competitiveness ISCIII grants (PI14/00860, CPII14/00005), Ministry of Economy, Industry and Competitiveness (PI17/01766), cofunded by ERDF (FEDER) Funds from the European Commission "A way of making Europe", Fundación Mapfre, Fundación Alicia Koplowitz (FAK2016/01), 'Delegación de Gobierno para el Plan Nacional sobre Drogas' (PNSD 2017/085), Comunidad de Madrid (BRADE-CM S2013/ICE-2958) and Fundación Tatiana Pérez de Guzmán el Bueno.
dc.format.extent 14
dc.language.iso eng
dc.publisher PLOS
dc.rights © 2018 Casquero-Veiga et al.
dc.rights This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights Atribución 3.0 España
dc.subject.other Deep brain stimulation
dc.subject.other Disease models
dc.subject.other Nucleus accumbens
dc.subject.other Obesity
dc.subject.other Positron-emission tomography
dc.subject.other Diagnostic imaging
dc.subject.other Rats
dc.subject.other Zucker rat
dc.title Stimulating the nucleus accumbens in obesity: a positron emission tomography study after deep brain stimulation in a rodent model
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess
dc.relation.projectID Gobierno de España. PI14/00860
dc.relation.projectID Gobierno de España. CPII14/00005
dc.relation.projectID Gobierno de España. PI17/01766
dc.relation.projectID Gobierno de España. PNSD 2017/085
dc.relation.projectID Comunidad de Madrid. S2013/ICE-2958
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue 9, e0204740
dc.identifier.publicationlastpage 14
dc.identifier.publicationtitle PLoS One
dc.identifier.publicationvolume 13
dc.identifier.uxxi AR/0000022250
dc.contributor.funder Comunidad de Madrid
dc.contributor.funder Ministerio de Economía y Competitividad (España)
dc.contributor.funder Plan Nacional sobre Drogas (España)
dc.contributor.funder Ministerio de Economía, Industria y Competitividad (España)
dc.affiliation.dpto UC3M. Departamento de Bioingeniería
dc.affiliation.grupoinv UC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Group
dc.affiliation.grupoinv UC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédica
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