Optimization design of a calibration for quantitative radiography

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dc.contributor.author Martinez Sanchez, Cristobal
dc.contributor.author Molina Gomez, Claudia De
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Abella García, Mónica
dc.date.accessioned 2021-04-26T09:23:32Z
dc.date.available 2022-03-01T00:00:04Z
dc.date.issued 2021-03
dc.identifier.bibliographicCitation Martinez, C., Molina, C., Desco, M. & Abella, M. (2021). Optimization of a calibration phantom for quantitative radiography. Medical Physics, 48(3), 1039-1053.
dc.identifier.issn 0094-2405
dc.identifier.uri http://hdl.handle.net/10016/32479
dc.description.abstract OBJECTIVE Dual energy radiography (DER) makes it possible to obtain separate images for soft‐tissue and bony structures (tissue maps) based on the acquisition of two radiographs at different source peak‐kilovoltage values. Current DER studies are based on the weighted subtraction method, which requires either manual tuning or the use of precomputed tables, or on decomposition methods, which make use of a calibration to model soft‐tissue and bone components. In this study, we examined in depth the optimum method to perform this calibration. METHODS We used simulations to optimize the calibration protocol and evaluated the effect of the material and size of a calibration phantom composed of two wedges and its positioning in the system. Evaluated materials were water, PMMA and A‐150 as soft‐tissue equivalent, and Teflon, B‐100 and aluminum as bone equivalent, with sizes from 5 to 30 cm. Each material combination was compared with an ideal phantom composed of soft tissue and bone. Our simulation results enabled us to propose four designs that were tested with the NOVA FA X‐ray system with a realistic thorax phantom. RESULTS Calibration based on a very simple and inexpensive phantom with no strict requirements in its placement results in appropriate separation of the spine (a common focus in densitometry studies) and the identification of nodules as small as 6 mm, which have been reported to have a low rate of detection in radiography. CONCLUSION The proposed method is completely automatic, avoiding the need for a radiology technician with expert knowledge of the protocol, as is the case in densitometry exams. The method provides real mass thickness values, enabling quantitative planar studies instead of relative comparisons.
dc.description.sponsorship This work was supported by Ministerio de Ciencia, Innovación y Universidades, Agencia Estatal de Investigación, projects “DPI2016‐79075‐R ‐ AEI/FEDER, UE”, Instituto de Salud Carlos III, project “DTS17/00122”, co funded by European Regional Development Fund (ERDF), “A way of making Europe”. Also partially supported by project “DEEPCT‐CM‐UC3M”, funded by the call “Programa de apoyo a la realización de proyectos interdisciplinares de I+D para jóvenes investigadores de la Universidad Carlos III de Madrid 2019‐2020 en el marco del Convenio Plurianual Comunidad de Madrid ‐ Universidad Carlos III de Madrid” and project “RADCOV19”, funded by CRUE Uiversidades, CSIC and Banco Santader (Fondo Supera). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (“SEV‐2015‐0505”). We thank Carlos Cobos Pérez for his help with the manufacturing of the calibration phantoms.
dc.format.extent 15
dc.language.iso eng
dc.publisher Wiley
dc.rights © 2021 American Association of Physicists in Medicine.
dc.subject.other Calibration
dc.subject.other Dual energy
dc.subject.other Quantitative radiography
dc.subject.other X-Ray
dc.title Optimization design of a calibration for quantitative radiography
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi https://doi.org/10.1002/mp.14638
dc.rights.accessRights openAccess
dc.relation.projectID Gobierno de España. DPI2016-79075-R
dc.relation.projectID Comunidad de Madrid. DEEPCT-CM-UC3M
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 1039
dc.identifier.publicationissue 3
dc.identifier.publicationlastpage 1053
dc.identifier.publicationtitle Medical Physics
dc.identifier.publicationvolume 48
dc.identifier.uxxi AR/0000027031
dc.contributor.funder Ministerio de Economía y Competitividad (España)
dc.contributor.funder Comunidad de Madrid
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