Is malarial anaemia homologous to neocytolysis after altitude acclimatisation?

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dc.contributor.author Fernandez Arias, Cristina
dc.contributor.author Fernández Arias, Clemente
dc.contributor.author Rodriguez, Ana
dc.date.accessioned 2020-07-20T09:39:46Z
dc.date.available 2020-07-20T09:39:46Z
dc.date.issued 2014-01-01
dc.identifier.bibliographicCitation International Journal for Parasitoloty, 2014, 44 (1), pp. 19-22
dc.identifier.issn 0020-7519
dc.identifier.uri http://hdl.handle.net/10016/30714
dc.description.abstract Malaria patients frequently develop severe anaemia that can persist after Plasmodium infection has been cleared from the circulation. This puzzling phenomenon involves massive death of young uninfected erythrocytes at a time when parasitic infection is very low. We have observed striking similarities in erythrocyte homoeostasis during altitude acclimatisation and Plasmodium infection, both of which initially induce an increase in circulating erythropoietin (Epo). Decreasing levels of Epo after return to low altitudes induce the death of young erythrocytes, a phenomenon called neocytolysis. In a similar way, we propose that Epo, which peaks during acute malaria and decreases after parasite clearance, could be contributing to anaemia causing neocytolysis during recovery from Plasmodium infection. (C) 2013 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
dc.language.iso eng
dc.rights © 2013 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
dc.subject.other Erythropoietin
dc.subject.other Acclimation
dc.subject.other Anemia
dc.subject.other Malaria
dc.subject.other Parasite
dc.subject.other Protozoan
dc.subject.other Altitude acclimatization
dc.subject.other Anemia
dc.subject.other Cell hypoxia
dc.subject.other Cytolysis
dc.subject.other Disease course
dc.subject.other Disease severity
dc.subject.other Erythrocyte metabolism
dc.subject.other Feedback system
dc.subject.other Human
dc.subject.other Malaria
dc.subject.other Neocytolysis
dc.subject.other Oxygen concentration
dc.subject.other Oxygen consumption
dc.subject.other Parasite clearance
dc.subject.other Pathophysiology
dc.subject.other Altitude acclimatisation
dc.subject.other Anaemia
dc.subject.other Malaria
dc.subject.other Neocytolysis
dc.subject.other Plasmodium
dc.title Is malarial anaemia homologous to neocytolysis after altitude acclimatisation?
dc.type article
dc.subject.eciencia Matemáticas
dc.identifier.doi https://doi.org/10.1016/j.ijpara.2013.06.011
dc.rights.accessRights closedAccess
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 19
dc.identifier.publicationissue 1
dc.identifier.publicationlastpage 22
dc.identifier.publicationtitle International Journal for Parasitoloty
dc.identifier.publicationvolume 44
dc.identifier.uxxi AR/0000014667
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