Graphene oxide and graphene reinforced PMMA bone cements: evaluation of thermal properties and biocompatibility

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dc.contributor.author Paz, Eva
dc.contributor.author Ballesteros Iglesias, Yolanda
dc.contributor.author Abenojar Buendía, Juana
dc.contributor.author Real Romero, Juan Carlos del
dc.contributor.author Dunne, Nicholas J.
dc.date.accessioned 2020-05-13T13:26:48Z
dc.date.available 2020-05-13T13:26:48Z
dc.date.issued 2019-09-26
dc.identifier.bibliographicCitation Materials, 12(19), 3146, Sept. 2019 (Special issue Graphene oxide: synthesis, reduction, and frontier applications)
dc.identifier.issn 1996-1944
dc.identifier.uri http://hdl.handle.net/10016/30381
dc.description.abstract The incorporation of well-dispersed graphene oxide (GO) and graphene (G) has been demonstrated as a promising solution to improve the mechanical performance of polymethyl methacrylate (PMMA) bone cements in an attempt to enhance the long-term survival of the cemented orthopaedic implants. However, to move forward with the clinical application of graphene-based PMMA bone cements, it is necessary to ensure the incorporation of graphene-based powders do not negatively affect other fundamental properties (e.g., thermal properties and biocompatibility), which may compromise the clinical success of the implant. In this study, the effect of incorporating GO and G on thermal properties, biocompatibility, and antimicrobial activity of PMMA bone cement was investigated. Differential scanning calorimetry studies demonstrated that the extent of the polymerisation reaction, heat generation, thermal conductivity, or glass transition temperature were not significantly (p > 0.05) affected by the addition of the GO or G powders. The cell viability showed no significant difference (p > 0.05) in viability when MC3-T3 cells were exposed to the surface of G- or GO-PMMA bone cements in comparison to the control. In conclusion, this study demonstrated the incorporation of GO or G powder did not significantly influence the thermal properties or biocompatibility of PMMA bone cements, potentially allowing its clinical progression.
dc.format.extent 14
dc.language.iso eng
dc.publisher MDPI
dc.rights © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.rights This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license
dc.rights Reconocimiento 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/
dc.subject.other Bone cement
dc.subject.other Graphene oxide
dc.subject.other Thermal properties
dc.subject.other Thermal Ccnductivity
dc.subject.other Kinetics
dc.subject.other Biocompatibility
dc.title Graphene oxide and graphene reinforced PMMA bone cements: evaluation of thermal properties and biocompatibility
dc.type article
dc.subject.eciencia Materiales
dc.identifier.doi https://doi.org/10.3390/ma12193146
dc.rights.accessRights openAccess
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue 19 (3146)
dc.identifier.publicationlastpage 14
dc.identifier.publicationtitle Materials
dc.identifier.publicationvolume 12
dc.identifier.uxxi AR/0000024539
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