Evaluation of the use of goat’s milk-derived exosomes as theragnostic platform in oncology

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dc.contributor.advisor Salinas Rodrígez, Beatriz
dc.contributor.advisor Cusso Mula, Lorena
dc.contributor.author Cañadas Ortega, Marina
dc.date.accessioned 2019-11-05T17:38:26Z
dc.date.available 2019-11-05T17:38:26Z
dc.date.issued 2018-06-18
dc.date.submitted 2018-07-02
dc.identifier.uri http://hdl.handle.net/10016/29132
dc.description.abstract Exosomes are biologically active nanovesicles from endosomal origin and lipid bilayer involved in cell communication, secreted by different types of cells and present in a wide variety of biological fluids. Due to their size, liposome-like characteristics and their strong relation with oncology, new applications for therapy and diagnosis are being explored in the field of medical imaging. During this thesis, the isolation, characterization and functionalization with fluorescent dyes has been performed to examine the possibility of using goat’s milk derived exosomes as theragnostic platform. With this purpose, the size, shape and charge of exosomes have been characterized, and the conjugation with two different fluorophores has proved to unalter their physicochemical properties. The biodistribution of functionalized exosomes, their toxicity and in vitro accumulation have been analyzed to evaluate that these nanovesicles can be used not only for diagnosis, but also for therapy and drug delivery in the future.
dc.language.iso eng
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Exosomes
dc.subject.other Nanotecnología
dc.subject.other Nanocarrier
dc.subject.other Extracellular vesicles
dc.subject.other Drug delivery systems
dc.title Evaluation of the use of goat’s milk-derived exosomes as theragnostic platform in oncology
dc.type bachelorThesis
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess
dc.description.degree Ingeniería Biomédica (Plan 2010)
dc.contributor.departamento Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial
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