The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance

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dc.contributor.author Arias, Clemente F.
dc.contributor.author Herrero, Miguel A.
dc.contributor.author Cuesta, José A.
dc.contributor.author Acosta, Francisco J.
dc.contributor.author Fernandez Arias, Cristina
dc.date.accessioned 2019-07-12T08:15:52Z
dc.date.available 2019-07-12T08:15:52Z
dc.date.issued 2015-07-08
dc.identifier.bibliographicCitation Arias, C. F., Herrero, M. A., Cuesta, J.A.,Acosta, F.J. y Fernández-Arias, C. (2015). The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance. Royal Society Open Science, 2(7), 150016.
dc.identifier.uri http://hdl.handle.net/10016/28582
dc.description.abstract Adaptive immune responses depend on the capacity of T cells to target specific antigens. As similar antigens can be expressed by pathogens and host cells, the question naturally arises of how can T cells discriminate friends from foes. In this work, we suggest that T cells tolerate cells whose proliferation rates remain below a permitted threshold. Our proposal relies on well-established facts about T-cell dynamics during acute infections: T-cell populations are elastic (they expand and contract) and they display inertia (contraction is delayed relative to antigen removal). By modelling inertia and elasticity, we show that tolerance to slow-growing populations can emerge as a population-scale feature of T cells. This result suggests a theoretical framework to understand immune tolerance that goes beyond the self versus non-self dichotomy.
dc.description.sponsorship M.A.H. has been partially supported by MINECO grant no. MTM2014-53156. The rest of the authors have not received any particular financial support for this work.
dc.format.extent 8
dc.language.iso eng
dc.publisher The Royal Society Publishing
dc.rights © 2015 The Authors.
dc.rights Atribución 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by/3.0/es/
dc.subject.other Negative selection
dc.subject.other T cells
dc.subject.other Immune self
dc.subject.other Immunodominance
dc.subject.other Immune tolerance
dc.title The growth threshold conjecture: a theoretical framework for understanding T-cell tolerance
dc.type article
dc.subject.eciencia Matemáticas
dc.identifier.doi https://doi.org/10.1098/rsos.150016
dc.rights.accessRights openAccess
dc.relation.projectID Gobierno de España. MTM2014-53156
dc.type.version publishedVersion
dc.identifier.publicationissue 2
dc.identifier.publicationtitle Royal Society Open Science
dc.identifier.uxxi AR/0000019949
dc.contributor.funder Ministerio de Economía y Competitividad (España)
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