In-vitro study of the bioactivity and cytotoxicity response of Ti surfaces modified by Nb and Mo diffusion treatments

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dc.contributor.author Ureña Alcázar, Julia María
dc.contributor.author Tsipas, Sophia Alexandra
dc.contributor.author Jiménez Morales, Antonia
dc.contributor.author Gordo Odériz, Elena
dc.contributor.author Rainer, Detsch
dc.contributor.author Boccaccini, Aldo
dc.date.accessioned 2018-09-19T10:48:48Z
dc.date.available 2020-02-15T00:00:03Z
dc.date.issued 2018-02-15
dc.identifier.bibliographicCitation Surface and Coatings Technology, 335, (2018), pp. 148-158.
dc.identifier.issn 0257-8972
dc.identifier.uri http://hdl.handle.net/10016/27442
dc.description.abstract This work focuses on the bioactivity and biological response of modified Ti surfaces produced by powder metallurgy. They are processed by diffusion of two beta-stabilizing elements, Nb and Mo, deposited onto the surface of PM Ti substrates. Moreover, the addition of an activating agent, NH4Cl, to the suspension has been carried out by thermo-reactive diffusion process. The surface modification led to a gradient in composition (Ti-Nb or Ti-Mo) and microstructure (beta / alpha + beta / alpha phases). This work presents the bioactivity results of these Ti-Mo and Ti-Nb surfaces as well as the cell-material response of the Ti-Nb surfaces. The reactivity of the materials was tested through immersion in simulated body fluid considering Ca and P precipitation in order to assess the ability of the materials to induce hydroxyapatite formation. The in-vitro cell response was evaluated by human osteoblast-like cells incubation on the different surfaces for 48 h. The investigation led to positive results in terms of surface bioactivity and an improved cell-material interaction of the PM modified Ti-Nb surfaces compared to the reference Ti material.
dc.description.sponsorship The authors would like to thank the funding provided for this research by the Regional Government of Madrid (program MULTIMAT-CHALLENGE-CM, ref. S2013/MIT-2862), and by the University Carlos III of Madrid for the research stay of three months in the Institute of Biomaterials (University of Erlangen-Nurnberg).
dc.format.extent 10
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof http://hdl.handle.net/10016/27609
dc.rights © 2017 Elsevier B.V. All rights reserved.
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Beta-Gradient titanium
dc.subject.other Surface modification
dc.subject.other Nb and Mo surface treatments
dc.subject.other Niobium
dc.subject.other Molybdenum
dc.subject.other Cytotoxicity
dc.subject.other Bioactivity
dc.subject.other In Vitro tests
dc.title In-vitro study of the bioactivity and cytotoxicity response of Ti surfaces modified by Nb and Mo diffusion treatments
dc.type article
dc.subject.eciencia Materiales
dc.identifier.doi https://doi.org/10.1016/j.surfcoat.2017.12.009
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2013/MIT-2862/MULTIMAT-CHALLENGE-CM
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 148
dc.identifier.publicationlastpage 158
dc.identifier.publicationtitle Surface & Coatings Technology
dc.identifier.publicationvolume 335
dc.identifier.uxxi AR/0000021050
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