Perfusion bioreactor for liver bioengineering

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dc.contributor.advisor Cañizo López, Juan Francisco del
dc.contributor.advisor Baptista Almeida de Matos, Pedro Cancio Villalonga, David 2018-06-26T10:57:39Z 2018-06-26T10:57:39Z 2016-09 2016-10-10
dc.description.abstract End-stage organ failure has grown to become one of the key challenges for the medical community because of the high number of patients in waiting list for a transplant and the severe shortage of suitable organ donors. These, together with population ageing, have created an accumulation phenomenon of patients which increases the severity of the problem. New techniques for organ preservation, organ recovery from organs not suitable for transplant, and organ recellularization attempt to tackle this problem, appearing as some of the most promising solutions. The aim of this bachelor thesis is to continue the development of a complex liver perfusion bioreactor in order to design and develop an efficient and repeatable method for organ perfusion, decellularization and recellularization, with the final objective being the creation of a perfusion bioreactor for liver bioengineering able to be used for organ perfusion and preservation, organ decellularization and organ recellularization, able to preserve cell structure, functionality, growth and control differentiation for up to 4 weeks, while avoiding contamination and automating as much as possible the process. In order to do this, the bioreactor will include many sensors and data acquisition systems as well as control systems for pressure, flow rate, and temperature among others.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.subject.other Liver perfusion bioreactor
dc.subject.other Organ perfusion and preservation
dc.subject.other Preservation of cell structure
dc.title Perfusion bioreactor for liver bioengineering
dc.type bachelorThesis
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess Ingeniería Biomédica
dc.contributor.departamento Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial
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