Electric fields on collective cell migration in epithelial cell monolayers

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dc.contributor.advisor Valencia Blanco, Leticia
dc.contributor.author Castro Gómez, Juan Manuel
dc.date.accessioned 2018-04-11T14:35:23Z
dc.date.available 2018-04-11T14:35:23Z
dc.date.issued 2014-07-07
dc.date.submitted 2014-07-07
dc.identifier.uri http://hdl.handle.net/10016/26624
dc.description.abstract Endogenous electric fields induced during wound healing seem to be one of the most relevant cues for the process. It has also been observed that the induction of external fields affects wound healing usual performance. However, the electric behavior of wounds has not been quantitatively modeled yet in a precise way. The current work is focused on the study in keratinocyte monolayers of both, electrical signaling after injury and cell behavior under the effect of induced electric fields. The results show that potential differences are generated during wound healing of keratinocyte monolayers, being the potential higher inside the wound than in the cellular region. Regarding voltage induction, the cell behavior is affected by the potential difference produced, being the range from 0 to 150 mV the most interesting for reepithelialization enhancement. This project is aimed to be the starting point of a much bigger one: the design of a device to control skin behavior during wound healing. Now, such a complex objective is still very far away, but the results lead to believe that it is an achievable goal.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Skin
dc.subject.other Espectroscopía
dc.subject.other Ingeniería biomédica
dc.subject.other Tissue engineering
dc.subject.other Cellular monolayers
dc.title Electric fields on collective cell migration in epithelial cell monolayers
dc.type bachelorThesis
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess
dc.description.degree Ingeniería Biomédica
dc.contributor.departamento Universidad Carlos III de Madrid. Departamento de Bioingeniería e Ingeniería Aeroespacial
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