Departamento/Instituto:
Universidad Carlos III de Madrid. Departamento de Teoría de la Señal y Comunicaciones Rheinisch-Westfälische Technische Hochschule Aachen
Derechos:
Atribución-NoComercial-SinDerivadas 3.0 España
Resumen:
A novel model of perfusion distribution in the lung and a novel model of ventilation distribution
are developed in this thesis. Both models are focused on the pressure distribution
along the thorax due to the gravitation.
The lung is divided into three zoneA novel model of perfusion distribution in the lung and a novel model of ventilation distribution
are developed in this thesis. Both models are focused on the pressure distribution
along the thorax due to the gravitation.
The lung is divided into three zones: upper zone, middle zone and lower zone. Blood flow
increses with the distance from the top of the lung. The upper zone is characterized by a
complete collapse of the pulmonary capillary vasculature, thus there is no flow in this zone.
The second zone have a “Waterfall effect”, the blood flow is determinated by the difference
between the pulmonary artery and alveolar pressures. In the lower zone, the flow is purely
driven by the difference between the pulmonary artery pressure and the pulmonary vein
pressure. In ventilation, the upper lobe of the lung are more expanded than the middle and
lower lobes at resting position. Consequently, ventilation during spontaneous breathing
was found nonuniform with more air entering the lower lobes than the middle and upper
lobes.
As a result, a complete model of perfusion and ventilation in the lung is created and the
results obtained in both models are in good agreement with the litetature. Both models are
implemented in the object-oriented modeling and simulation module Matlab Simscape.[+][-]