Fluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementation

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dc.contributor.author Gómez García, Pablo Aurelio
dc.contributor.author Arranz, Alicia
dc.contributor.author Fresno, Manuel
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Mahmood, Umar
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Ripoll Lorenzo, Jorge
dc.date.accessioned 2015-06-25T09:17:13Z
dc.date.available 2015-06-25T09:17:13Z
dc.date.issued 2015
dc.identifier.bibliographicCitation Kurachi, C., Svanberg, K. & Tromberg, B. J. (eds.) (2015). Biophotonics South America. Proceedings SPIE, vol . 9531, 9531111. Society of Photo-Optical Instrumentation Engineers
dc.identifier.isbn 9781628416961
dc.identifier.uri http://hdl.handle.net/10016/21187
dc.description Proceedings of: IPA 2015 / SPIE Biophotonics South America. Rio de Janeiro, Brazil, 22-26 May, 2015
dc.description.abstract Endoscopy is frequently used in the diagnosis of several gastro-intestinal pathologies as Crohn disease, ulcerative colitis or colorectal cancer. It has great potential as a non-invasive screening technique capable of detecting suspicious alterations in the intestinal mucosa, such as inflammatory processes. However, these early lesions usually cannot be detected with conventional endoscopes, due to lack of cellular detail and the absence of specific markers. Due to this lack of specificity, the development of new endoscopy technologies, which are able to show microscopic changes in the mucosa structure, are necessary. We here present a confocal endomicroscope, which in combination with a wide field fluorescence endoscope offers fast and specific macroscopic information through the use of activatable probes and a detailed analysis at cellular level of the possible altered tissue areas. This multi-modal and multi-scale imaging module, compatible with commercial endoscopes, combines near-infrared fluorescence (NIRF) measurements (enabling specific imaging of markers of disease and prognosis) and confocal endomicroscopy making use of a fiber bundle, providing a cellular level resolution. The system will be used in animal models exhibiting gastro-intestinal diseases in order to analyze the use of potential diagnostic markers in colorectal cancer. In this work, we present in detail the set-up design and the software implementation in order to obtain simultaneous RGB/NIRF measurements and short confocal scanning times.
dc.description.sponsorship The authors acknowledge support from EC FP7 IMI project PREDICT-TB, the EC FP7 CIG grant HIGH-THROUGHPUT TOMO, the Spanish MINECO project grant FIS2013-41802-R MESO-IMAGING, and TOPUS S2013/MIT-3024 project from the regional government of Madrid
dc.format.extent 10
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Spie- The International Society For Optical Engineering
dc.rights © 2015. SPIE. Society of Photo-Optical Instrumentation Engineers.
dc.subject.other Endoscopy
dc.subject.other Endomicroscopy
dc.subject.other Fiber bundle
dc.subject.other Fluorescence
dc.subject.other Scan
dc.subject.other Software
dc.subject.other Cell imaging
dc.title Fluorescence multi-scale endoscopy and its applications in the study and diagnosis of gastro-intestinal diseases: set-up design and software implementation
dc.type bookPart
dc.type conferenceObject
dc.description.status Publicado
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi http://dx.doi.org/10.1117/12.2189960
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2013/MIT-3024/TOPUS
dc.relation.projectID Gobierno de España. FIS2013-41802-R
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/333632
dc.type.version publishedVersion
dc.relation.eventdate 22-26 May, 2015
dc.relation.eventplace Rio de Janeiro, Brazil
dc.relation.eventtitle IPA 2015 / SPIE Biophotonics South America
dc.relation.eventtype proceeding
dc.identifier.publicationtitle Biophotonics South America. Proceedings SPIE
dc.identifier.publicationvolume 9531
dc.identifier.uxxi CC/0000023802
dc.affiliation.dpto UC3M. Departamento de Bioingeniería
dc.affiliation.grupoinv UC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Group
dc.affiliation.grupoinv UC3M. Grupo de Investigación: BSEL - Laboratorio de Ciencia e Ingeniería Biomédica
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