Applicability of bioengineered human skin: from preclinical skin humanized mouse models to clinical regenerative therapies

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Show simple item record Río Nechaevsky, Marcela del Guerrero-Aspizua, S. Carretero, Marta 2015-03-12T12:00:05Z 2015-03-12T12:00:05Z 2011-07-01
dc.identifier.bibliographicCitation Bioengineered bugs (2011), vol.2, nº4, pp, 203-207
dc.identifier.issn 2165-5979 (Print)
dc.identifier.issn 1949-1018 (Online)
dc.description.abstract Ongoing progress in the field of regenerative medicine, in combination with the development of tissue-engineered skin products, has opened new possibilities for the treatment of certain diseases in which current treatments are aimed at alleviating symptoms but are not able to get a permanent cure. Our laboratory has developed a fibrin-based bioengineered human skin that has been successfully used for permanent regenerative therapies in different situations in the clinic. Moreover, we have been able to stably regenerate human skin by orthotopic grafting of this skin equivalent onto the back of immunodeficient mice. The so-called skin-humanized mouse model system has permitted us to model several monogenic skin diseases, when keratinocytes and fibroblasts harboring the genetic defect were used. In most cases different gene therapy approaches for ex vivo correction of cells have proved effective in reverting the phenotype using this model. More importantly, the feasibility of the system has allowed us to generate a skin humanized mouse model for psoriasis, a common chronic inflammatory disease where the immune component has a pivotal role in the pathogenesis. Establishing reliable humanized animal models for skin diseases is necessary to gain a deeper knowledge of the pathogenesis and to develop novel therapeutic strategies. In this sense, the skin humanized mouse model developed in our laboratory meets the needs of this field of research.
dc.description.sponsorship This work was supported by grant SAF 2010-16976.
dc.format.extent 6
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Taylor & Francis
dc.rights © 2011 Landes Bioscience
dc.subject.other Bioengineering
dc.subject.other Psoriasis
dc.subject.other Innovative animal models
dc.subject.other Keratinocytes
dc.subject.other Lymphocytes subpopulations
dc.title Applicability of bioengineered human skin: from preclinical skin humanized mouse models to clinical regenerative therapies
dc.type article
dc.subject.eciencia Biología y Biomedicina
dc.subject.eciencia Medicina
dc.identifier.doi 10.4161/bbug.2.4.16112
dc.rights.accessRights openAccess
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 203
dc.identifier.publicationissue 4
dc.identifier.publicationlastpage 207
dc.identifier.publicationtitle Bioengineered bugs
dc.identifier.publicationvolume 2
dc.identifier.uxxi AR/0000012907
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