Struggle for space: viral extinction through competition for cells

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dc.contributor.author Cuesta, José A.
dc.contributor.author Aguirre, Jacobo
dc.contributor.author Capitán, José A.
dc.contributor.author Manrubia, Susanna C.
dc.date.accessioned 2014-06-09T11:21:00Z
dc.date.available 2014-06-09T11:21:00Z
dc.date.issued 2011-01-14
dc.identifier.bibliographicCitation Physical review letters, 106 (2), pp. 028104
dc.identifier.issn 0031-9007
dc.identifier.uri http://hdl.handle.net/10016/18967
dc.description.abstract The design of protocols to suppress the propagation of viral infections is an enduring enterprise, especially hindered by limited knowledge of the mechanisms leading to viral extinction. Here we report on infection extinction due to intraspecific competition to infect susceptible hosts. Beneficial mutations increase the production of viral progeny, while the host cell may develop defenses against infection. For an unlimited number of host cells, a feedback runaway coevolution between host resistance and progeny production occurs. However, physical space limits the advantage that the virus obtains from increasing offspring numbers; thus, infection clearance may result from an increase in host defenses beyond a finite threshold. Our results might be relevant to devise improved control strategies in environments with mobility constraints or different geometrical properties.
dc.description.sponsorship The authors acknowledge the support of the Spanish MICINN under projects FIS2008-05273 and MOSAICO and of Comunidad de Madrid (Spain) under project MODELICO-CM.
dc.format.extent 4
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © 2011 American Physical Society
dc.subject.other Error catastrophe
dc.subject.other Virus populations
dc.subject.other Evolution
dc.subject.other Supperssion
dc.subject.other Percolation
dc.subject.other Infectivity
dc.subject.other Resistance
dc.subject.other Threshold
dc.subject.other Genetics
dc.title Struggle for space: viral extinction through competition for cells
dc.type article
dc.relation.publisherversion http://dx.doi.org/10.1103/PhysRevLett.106.028104
dc.subject.eciencia Matemáticas
dc.subject.eciencia Medicina
dc.identifier.doi 10.1103/PhysRevLett.106.028104
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2009/ESP-1691/MODELICO
dc.relation.projectID Gobierno de España. FIS2008-05273
dc.relation.projectID Gobierno de España. FIS2006-01485/MOSAICO
dc.type.version publishedVersion
dc.identifier.publicationfirstpage 1
dc.identifier.publicationissue 2 (028104)
dc.identifier.publicationlastpage 4
dc.identifier.publicationtitle Physical review letters
dc.identifier.publicationvolume 106
dc.identifier.uxxi AR/0000007931
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