Skin bioengineering: preclinical and clinical application

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Show simple item record Martínez-Santamaría, L. Guerrero-Aspizua, S. Río Nechaevsky, Marcela del 2014-03-24T15:25:41Z 2014-03-24T15:25:41Z 2012-01
dc.identifier.bibliographicCitation Actas dermo-sifiliográficas, Vol. 103, nº 1, pp. 5-11
dc.identifier.issn 0001-7310
dc.description.abstract Regenerative Medicine is an emerging field that combines basic research and clinical observations in order to identify the elements required to replace damaged tissues and organs in vivo and to stimulate the body's intrinsic regenerative capacity. Great benefits are expected in this field as researchers take advantage of the potential regenerative properties of both embryonic and adult stem cells, and more recently, of induced pluripotent stem cells. Bioengineered skin emerged mainly in response to a critical need for early permanent coverage of extensive burns. Later this technology was also applied to the treatment of chronic ulcers. Our group has established a humanized mouse model of skin grafting that involves the use of bioengineered human skin in immunodeficient mice. This model is suitable for the study of physiologic and pathologic cutaneous processes and the evaluation of treatment strategies for skin diseases, including protocols for gene and cell therapy and tissue engineering.
dc.description.sponsorship Our work has been funded by the Spanish Department of Science and Innovation (SAF2007-61019 and SAF 2010-16976), by the Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), and by the Ministry of Health (Advanced Therapies Plan, TRA 0160).
dc.format.extent 7
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.rights © 2012 Elsevier España.
dc.subject.other Tissue engineering
dc.subject.other Regenerative medicine
dc.subject.other Stem cells
dc.subject.other Humanized mouse models of skin diseases
dc.subject.other Experimental dermatology
dc.title Skin bioengineering: preclinical and clinical application
dc.title.alternative Bioingeniería cutánea: aplicaciones preclínicas y clínicas
dc.type article
dc.subject.eciencia Medicina
dc.identifier.doi 10.1016/j.adengl.2011.03.01
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2010/BMD-2420/CELLCAM
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 5
dc.identifier.publicationissue 1
dc.identifier.publicationlastpage 11
dc.identifier.publicationtitle Actas dermo-sifiliográficas
dc.identifier.publicationvolume 103
dc.identifier.uxxi AR/0000012898
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