Measurement of myocardial wall thickening from PET/SPECT images: comparison of two methods

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dc.contributor.author Bartlett, Marisa L.
dc.contributor.author Buvat, Irene
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Mok, David
dc.contributor.author Vasken, Dilsizian
dc.contributor.author Bacharach, Stephen L.
dc.date.accessioned 2012-06-28T08:41:08Z
dc.date.available 2012-06-28T08:41:08Z
dc.date.issued 1996
dc.identifier.bibliographicCitation Journal of Computer Assisted Tomography, vol. 30, n. 3, may. - jun. 1996. Pp. 473-481
dc.identifier.issn 0363-8715 (print version)
dc.identifier.issn 1532-3145 (online version)
dc.identifier.uri http://hdl.handle.net/10016/14740
dc.description.abstract Purpose: We compared two methods for measuring myocardial wall thickening from nuclear medicine perfusion scans. The first method uses the percent change in peak activity, and the second method models a profile measured across the myocardium. Method: Mathematical simulations of the myocardium were used. In addition, images with PET or SPECT resolution were created from real MR images. Known amounts of noise were then added. Results: The percent peak thickening (%PT) is nonlinear with true percent thickening, especially for PET resolutions [7 mm full width at half-maximum (FWHM)]. For the peak method, low levels of noise (10%) introduced an error of 8%PT for PET and of 16%PT for SPECT. Additional smoothing reduced these errors. For the fitted model, at 10% noise, the error in thickening was large: 2.3 mm for PET and 7.8 mm for SPECT. Conclusion: The fitted model works well only with good resolution and low noise (e.g., 7 mm FWHM and 10%). The peak method is also sensitive to noise, especially for poorer resolutions. Additional smoothing gives more reliable results for the peak method but not the fitted method. The peak method is therefore the more generally reliable, but even this method may only allow classification of myocardial thickening into broad categories.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.rights Atribución-NoComercial-SinDerivadas 3.0 España
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.other Heart
dc.subject.other Emission computed tomography
dc.subject.other lmage registration
dc.title Measurement of myocardial wall thickening from PET/SPECT images: comparison of two methods
dc.type article
dc.description.status Publicado
dc.subject.eciencia Biología y Biomedicina
dc.rights.accessRights openAccess
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage 473
dc.identifier.publicationissue n. 3
dc.identifier.publicationlastpage 481
dc.identifier.publicationtitle Journal of Computer Assisted Tomography
dc.identifier.publicationvolume vol. 30
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