Sponsor:
This work was supported by grants from the Ministerio de Educación y Ciencia (Grants nº SAF2004-08148 and SAF2007-064890); Ministerio de Sanidad y Consumo (Grants RD06/ 00170029 of Instituto de Salud Carlos III, PNSD 2004 2007 and 2008 2010); Dirección General de Investigación de la Comunidad de Madrid (Grant S-SAL/0261/2006, I+D CANNAB-CM Consortium); and UNED (Plan de Promoción de la Investigación) to EA, and grants from the “Ministerio de Ciencia y Tecnología” (TEC2004-07052-C02-01/TCM), “Ministerio de Sanidad y Consumo” (CIBER CB06/01/0079, PNSD 2007 2010, FIS CP08/00017), “Ministerio de Industria” (CENIT program) and “Fundación de Investigación Médica Mutua Madrileña” (2007 2010 and 2008 2011) to MD.
Project:
Gobierno de España. SAF2004-08148 Gobierno de España. SAF2007-064890 Gobierno de España. RD06/00170029 Gobierno de España. TEC2004-07052-C02-01
Purpose: To analyze brain metabolic response to acute cocaine in male and female Wistar rats
with or without a history of cannabinoid exposure during periadolescence.
Procedures: The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were
admPurpose: To analyze brain metabolic response to acute cocaine in male and female Wistar rats
with or without a history of cannabinoid exposure during periadolescence.
Procedures: The synthetic cannabinoid agonist CP 55,940 (CP) or its vehicle (VH), were
administered to male and female rats during periadolescence. When these animals reached
adulthood, saline and cocaine-induced changes in 2-deoxy-2-[18F]fluoro D glucose (FDG)
uptake were studied by positron emission tomography.
Results: The baseline (post-saline) metabolism in the septal nuclei was higher in CP-females
than in VH-females, although septal metabolism was lower in CP-females after cocaine,
reaching similar values to those of VH-females at baseline. Cocaine did not affect metabolism in
VH-females. Periadolescent cannabinoid treatment did not influence baseline metabolism in
males although cocaine reduced the FDG uptake in the dorsal striatum of males that received
the VH but not CP.
Conclusions: These results suggest that cannabinoids during periadolescence modify baseline
and cocaine-evoked brain metabolism in a sex-dependent manner. In the case of CP-females,
the involvement of septal metabolic alterations in their susceptibility to the rewarding effects of
cocaine should be further investigated.[+][-]