Study of CT-based positron range correction in high resolution 3D PET imaging

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dc.contributor.author Cal González, Jacobo
dc.contributor.author Herraiz, J. L.
dc.contributor.author España, Samuel
dc.contributor.author Vicente, Esther
dc.contributor.author Herranz, Elena
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Udías, José Manuel
dc.date.accessioned 2012-06-26T10:32:28Z
dc.date.available 2012-06-26T10:32:28Z
dc.date.issued 2011-08-21
dc.identifier.bibliographicCitation Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 648, suplement 1, 21 august 2011. Pp. S172-S175
dc.identifier.issn 0168-9002
dc.identifier.uri http://hdl.handle.net/10016/14691
dc.description.abstract Positron range limits the spatial resolution of PET images and has a different effect for different isotopes and positron propagationmaterials. Therefore it is important to consider it during image reconstruction, in order to obtain optimal image quality. Positron range distributions for most common isotopes used in PET in different materials were computed using the Monte Carlo simulations with PeneloPET. The range profiles were introduced into the 3D OSEM image reconstruction software FIRST and employed to blur the image either in the forward projection or in the forward and backward projection. The blurring introduced takes into account the different materials in which the positron propagates. Information on these materials may be obtained, for instance, from a segmentation of a CT image. The results of introducing positron blurring in both forward and backward projection operations was compared to using it only during forward projection. Further, the effect of different shapes of positron range profile in the quality of the reconstructed images with positron range correction was studied. For high positron energy isotopes, the reconstructed images show significant improvement in spatial resolution when positron range is taken into account during reconstruction, compared to reconstructions without positron range modeling.
dc.description.sponsorship This work has been supported by the MEC (FPA2007 62216), the UCM (Grupos UCM, 910059), the CPAN (Consolider Ingenio 2010) CSPD 2007 00042, the RECAVA RETIC network, ARTEMIS S2009/ DPI 1802, the European Regional Development and ENTEPRASE grant, PSE 300000 2009 5 and the Ministerio de Ciencia e Innovación, Spanish Government.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.rights © Elsevier
dc.subject.other Positron Emission Tomography (PET)
dc.subject.other Computed Tomography (CT)
dc.subject.other Positron range
dc.subject.other Image quality
dc.subject.other Monte Carlo simulation
dc.title Study of CT-based positron range correction in high resolution 3D PET imaging
dc.type article
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1016/j.nima.2010.12.041
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1016/j.nima.2010.12.041
dc.rights.accessRights openAccess
dc.relation.projectID Comunidad de Madrid. S2009/DPI-1802/ARTEMIS
dc.relation.projectID Gobierno de España. FPA2007-62216
dc.relation.projectID Gobierno de España. PSE-300000-2009-5
dc.type.version acceptedVersion
dc.identifier.publicationfirstpage S172
dc.identifier.publicationissue suplement 1
dc.identifier.publicationlastpage S175
dc.identifier.publicationtitle Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
dc.identifier.publicationvolume vol. 648
dc.identifier.uxxi AR/0000012071
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