Performance evaluation for 68Ga and 18F of the ARGUS small-animal PET scanner based on the NEMA NU-4 standard

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dc.contributor.author Cañadas Castro, Mario
dc.contributor.author Romero Sanz, E.
dc.contributor.author Oteo Vives, M.
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Vicente, Esther
dc.contributor.author Udías, José Manuel
dc.contributor.author Romero, L.
dc.date.accessioned 2012-06-22T11:54:25Z
dc.date.available 2012-06-22T11:54:25Z
dc.date.issued 2010
dc.identifier.bibliographicCitation 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC), 2010. Pp. 3454 - 3457
dc.identifier.isbn 978-1-4244-9106-3
dc.identifier.issn 1095-7863
dc.identifier.uri http://hdl.handle.net/10016/14664
dc.description Proceeding of: 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference and 17th Room Temperature Semiconductor Detector Workshop (IEEE), Knoxville, Tennessee, USA, October 30 - November 6, 2010
dc.description.abstract 68Ga is one of the non-conventional nuclides that are being used in preclinical imaging. One disadvantage of 68Ga versus 18F is its larger positron range, which deteriorates the effective spatial resolution and the overall image quality. In this work we present a performance evaluation of the ARGUS smallanimal positron emission tomography (PET) scanner for two positron emitters, 68Ga and 18F. These experiments followed the procedure based on the National Electrical Manufacturers Association (NEMA) NU 4-2008 standard. We show how the use of 68Ga may affect the NEMA performance of the system in terms of image quality and spatial resolution. The recovery coefficients (RC) measured in the image-quality phantom ranged from 0.17 to 0.72 for 68Ga and from 0.28 to 0.92 for 18F, using iterative image reconstruction methods and applying all corrections. Under the same conditions the image noise (%STD) in a uniform region was 17.0% for 68Ga and 15.1% for 18F. The respective spillover ratios (SOR) were 0.13 and 0.09 in air, and 0.21 and 0.12 in water. Attenuation correction yielded an improvement of the SOR close to 50% for both radionuclides in the air-filled region. This work evaluates the image reconstruction methods and corrections available in the ARGUS PET for 68Ga and 18F to assess the influence of their physical properties on the NEMA parameters.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Performance evaluation for 68Ga and 18F of the ARGUS small-animal PET scanner based on the NEMA NU-4 standard
dc.type article
dc.type conferenceObject
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2010.5874448
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2010.5874448
dc.rights.accessRights openAccess
dc.type.version acceptedVersion
dc.relation.eventdate October 30 - November 6, 2010
dc.relation.eventplace Knoxville, Tennessee, USA
dc.relation.eventtitle 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference
dc.relation.eventtitle 17th Room Temperature Semiconductor Detector Workshop (IEEE)
dc.identifier.publicationfirstpage 3454
dc.identifier.publicationlastpage 3457
dc.identifier.publicationtitle 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
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