Validation of NEMA NU4-2008 Scatter Fraction estimation with 18F and 68Ga for the ARGUS smallanimal PET scanner

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dc.contributor.author Vicente, Esther
dc.contributor.author Herraiz, J. L.
dc.contributor.author Cañadas, Mario
dc.contributor.author Cal González, Jacobo
dc.contributor.author España, Samuel
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Udías, José Manuel
dc.date.accessioned 2012-06-22T10:44:19Z
dc.date.available 2012-06-22T10:44:19Z
dc.date.issued 2010
dc.identifier.bibliographicCitation 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC), 2010. Pp. 3553 - 3557
dc.identifier.isbn 978-1-4244-9106-3
dc.identifier.issn 1095-7863
dc.identifier.uri http://hdl.handle.net/10016/14662
dc.description Proceeding of: 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, Knoxville, Tennessee, USA, October 30 - November 6, 2010
dc.description.abstract The scatter fraction (SF) in PET data represents the fraction of coincidence events in which at least one of the two emitted photons have been scattered before being detected. It is usually estimated as the ratio of scattered events to total number of coincidences, when the number of random counts is negligible (less than 1% of true rates). SF provides a measurement of the relative sensitivity of the scanner to scattered radiation. It depends on object size, density and location inside the field of view, as well as on detector size, type of detector crystal and energy window. The performance evaluation guideline for smallanimal PET NEMA (National Electrical Manufacturers Association) NU4-2008 proposes the estimation of the SF for three test phantoms made in proportion to the most widely used small animals in the laboratory: mouse, rat and monkey. The method estimates the different coincidence types in sinogram profiles from an off-centered line source inserted in these phantoms. We benchmark the procedure proposed by NEMA to estimate SF with 18F and also with 68Ga, a radionuclide with lager positron range. Real data acquired with the ARGUS smallanimal PET scanner (SEDECAL, Madrid, Spain) as well as simulations of the same scanner with peneloPET are used. The results show that, though SF should be practically the same with both 18F and 68Ga isotopes (and indeed our simulations indicate this) NEMA SF estimations with 68Ga acquisitions are higher. This is due to the fact that 68Ga positron range affects on the width of the line source profiles. Suggestions to modify the protocol to obtain similar SF estimations when using isotopes with larger positron range than 18F are made.
dc.description.sponsorship This work has been supported by MEC (FPA2007-62216), UCM (Grupos UCM, 910059), CPAN (Consolider-Ingenio 2010) CSPD-2007-00042, European Regional Funds. AMIT Project funded by CDTI (CENIT Programme), ARTEMIS S2009/DPI-1802, European Regional Development and ENTEPRASE grant, PSE-300000-2009-5, Ministerio de Ciencia e Innovación. Spanish Government.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Validation of NEMA NU4-2008 Scatter Fraction estimation with 18F and 68Ga for the ARGUS smallanimal PET scanner
dc.type conferenceObject
dc.type article
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2010.5874470
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2010.5874470
dc.rights.accessRights openAccess
dc.type.version acceptedVersion
dc.relation.eventdate October 30 - November 6, 2010
dc.relation.eventplace Knoxville, Tennessee, USA
dc.relation.eventtitle 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference
dc.identifier.publicationfirstpage 3553
dc.identifier.publicationlastpage 3557
dc.identifier.publicationtitle 2010 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
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