Cita:
Plos One, vol. 6, n. 8, august 2011. Pp. 1-13
ISSN:
1932-6203 (online)
DOI:
10.1371/journal.pone.0023358
Agradecimientos:
Projects FIS2008 05273, MOSAICO, and Complexity NET RESINEE from Ministerio de Ciencia e Innovación (Spain), and MODELICO CM from Comunidad Autónoma de Madrid (Spain) provided funding
Derechos:
Atribución-NoComercial-SinDerivadas 3.0 España
Resumen:
The production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes
quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the
virus and theThe production of large progeny numbers affected by high mutation rates is a ubiquitous strategy of viruses, as it promotes
quick adaptation and survival to changing environments. However, this situation often ushers in an arms race between the
virus and the host cells. In this paper we investigate in depth a model for the dynamics of a phenotypically heterogeneous
population of viruses whose propagation is limited to two-dimensional geometries, and where host cells are able to
develop defenses against infection. Our analytical and numerical analyses are developed in close connection to directed
percolation models. In fact, we show that making the space explicit in the model, which in turn amounts to reducing viral
mobility and hindering the infective ability of the virus, connects our work with similar dynamical models that lie in the
universality class of directed percolation. In addition, we use the fact that our model is a multicomponent generalization of
the Domany-Kinzel probabilistic cellular automaton to employ several techniques developed in the past in that context,
such as the two-site approximation to the extinction transition line. Our aim is to better understand propagation of viral
infections with mobility restrictions, e.g., in crops or in plant leaves, in order to inspire new strategies for effective viral
control.[+][-]