Publisher:
Dimitris N. Metaxas, Ross T. Whitaker, Jens Rittcher, Thomas Sebastian
Issued date:
2006
Citation:
Microscopic image analysis with applications in biology : First international workshop, MIAAB 2006, (Copenaghe, Danemark, October 5, 2006), 2006, p. 1-4
Rights:
Atribución-NoComercial-SinDerivadas 3.0 España
Abstract:
The evaluation of new therapies to treat allergic
asthma makes frequent use of histological studies. Some of
these studies are based on the microscope observation of
stained paraffin lung sections to quantify cellular infiltration,
an effect directly relatThe evaluation of new therapies to treat allergic
asthma makes frequent use of histological studies. Some of
these studies are based on the microscope observation of
stained paraffin lung sections to quantify cellular infiltration,
an effect directly related to allergic processes. To our
knowledge, there is no software tool for doing this
quantification automatically nowadays. This paper presents a
method for the quantification of cellular infiltrate of lung
tissue images in a mouse model of allergic asthma. Each image
is divided into regions of equal size that are classified by means
of a segmentation algorithm based on texture analysis. The
classification uses three discriminant functions, built from
parameters derived from the histogram and the co-occurrence
matrix and calculated by performing an initial stepwise
discriminant analysis on 79 samples from a training set.
Results provide a correct classification of 96.8 % on an
independent test set of 251 samples labeled manually.[+][-]
Description:
Proceedings of: The first international workshop on Microscopic Image Analysis with Applications in Biology, MIAAB 2006, was held in Copenhagen, Denmark, on 5th of October 2006 as an associated workshop of MICCAI 2006, the 9th Conference held by the international society of Medical Image Computing and Computer-Assisted Intervention.