Normalization in 3D PET: dependence on the activity distribution of the source

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dc.contributor.author Vicente, Esther
dc.contributor.author Vaquero López, Juan José
dc.contributor.author España, Samuel
dc.contributor.author Herraiz, J. L.
dc.contributor.author Udías, José Manuel
dc.contributor.author Desco Menéndez, Manuel
dc.date.accessioned 2011-10-06T09:50:32Z
dc.date.available 2011-10-06T09:50:32Z
dc.date.issued 2007
dc.identifier.bibliographicCitation 2006 IEEE Nuclear Science Symposium Conference Record, 2006, vol. 4, p. 2206 - 2209
dc.identifier.isbn 1-4244-0560-2
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12239
dc.description Proceeding of: 2006 IEEE Nuclear Science Symposium Conference Record, San Diego, CA, Oct. 29 - Nov. 1, 2006
dc.description.abstract In this communication we show the dependence of the normalization of 3D small animal PET scanners on the calibrating source geometry and non-uniformity of the activity distribution inside it. The potential impact on the reconstructed images of deviations from the ideal activity is discussed. Results from simulated and real data for a pair of block detectors suggest that planar or annular sources can be equally suitable for a normalization procedure if their geometry and their intersections with the system lines-of-response (LORs) are properly taken into account. When comparing an annulus with a centered planar source, both filled with the same total activity, the planar source produces twice the count rate with a 92% of trues versus 66% of trues for the annulus. Scatter and randoms are lower by factors of 3 and 4 respectively in the planar case. We conclude that, although planar and annular sources can be suitable for a normalization procedure if their geometries are properly taken into account, planar source normalization results are better than those of an annulus, particularly if the normalization does not consider the effect of scatter correction, more significant for the annulus source than for the planar one
dc.description.sponsorship This work has been partially funded by projects PI052583 and PI052583 (Ministerio de Sanidad), BFM2003-04147-C02-01 (Ministerio de Edcucación y Ciencia) and CD-TEAM (Ministerio de Industria, CENIT program), Spain
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Normalization in 3D PET: dependence on the activity distribution of the source
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2006.354352
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2006.354352
dc.rights.accessRights openAccess
dc.relation.eventdate October 29 - November 1, 2006
dc.relation.eventplace San Diego, CA
dc.relation.eventtitle 2006 IEEE Nuclear Science Symposium Conference Record
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 2206
dc.identifier.publicationlastpage 2209
dc.identifier.publicationtitle 2006 IEEE Nuclear Science Symposium Conference Record
dc.identifier.publicationvolume 4
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