Accuracy of CT-based attenuation correction in bone imaging with PET/CT

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dc.contributor.author Abella García, Mónica
dc.contributor.author Mankof, D.
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Kinahan, P. E.
dc.date.accessioned 2011-10-05T15:05:26Z
dc.date.available 2011-10-05T15:05:26Z
dc.date.issued 2007
dc.identifier.bibliographicCitation 2007 IEEE Nuclear Science Symposium Conference Record, 2007, vol. 6, p. 4485 - 4488
dc.identifier.isbn 978-1-4244-0922-8
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12234
dc.description Proceeding of: 2007 IEEE Nuclear Science Symposium Conference Record (NSS'07), Honolulu, Hawaii, USA, Oct. 27 - Nov. 3, 2007
dc.description.abstract PET/CT has become the most comprehensive diagnostic tool in oncology imaging providing improved lesion identification and localization. Bone is a common site of metastasis and the quantitative accuracy of PET images in bone tissue is important for assessing response to therapy. The use of CT images for attenuation correction is becoming a standard procedure in these scanners. However the impact of CT-based attenuation correction (CTAC) on the accuracy of PET tracer uptake values measured in bone has not been carefully evaluated, having only been carefully studied in soft tissue. We investigated the accuracy of CTAC on PET bone images by comparing the attenuation coefficients with PET transmission scans. For this, we imaged frozen bovine femur segments in a 20x20 cm cylindrical phantom. Different regions of the bones in both images were segmented by using thresholding and erosion methods to get equivalent volume masks. Differences in linear attenuation coefficients between the two images were then calculated. We repeated this analysis using patient images from the same patient imaged on the GE Advance PET scanner and the GE Discovery STE PET/CT scanner. The impact of the errors in the linear attenuation coefficients on PET SUV measurements was evaluated by simulations using the patent images with known bone disease and elevated levels of FDG uptake in bone (e.g. SUV = 5) at disease sites. The impact of the errors in the linear attenuation coefficients was then estimated by forward projection and reconstruction, after including the effects of attenuation and attenuation correction.
dc.description.sponsorship This work was supported in kart by Agencia Antidroga de la Comunidad de Madrid (S-SAL2007), Ministerio de Sanidad y Consumo (CIBER CB06/01/0079), and Ministerio de Industria (Programa CENIT). It was also supported in part by NIH grants R01- CA124573 and R01-CA115870.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.subject.other Positron Emission Tomography (PET)
dc.subject.other Image registration
dc.title Accuracy of CT-based attenuation correction in bone imaging with PET/CT
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2007.4437107
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2007.4437107
dc.rights.accessRights openAccess
dc.relation.eventdate Oct. 27 - Nov. 3, 2007
dc.relation.eventplace Honolulu, Hawaii, USA
dc.relation.eventtitle 2007 IEEE Nuclear Science Symposium Conference Record (NSS'07)
dc.identifier.publicationfirstpage 4485
dc.identifier.publicationlastpage 4488
dc.identifier.publicationtitle 2007 IEEE Nuclear Science Symposium Conference Record
dc.identifier.publicationvolume 6
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