Influence of random, pile-up and scatter corrections in the quantification properties of small animal PET scanners

e-Archivo Repository

Show simple item record Vicente, Esther Soto Montenegro, M. L. España, Samuel Herraiz, J. L. Herranz, Elena Vaquero López, Juan José Desco Menéndez, Manuel Udías, José Manuel 2011-10-05T12:47:42Z 2011-10-05T12:47:42Z 2007
dc.identifier.bibliographicCitation 2007 IEEE Nuclear Science Symposium Conference Record, 2007, vol. 5, p. 3964 - 3968
dc.identifier.isbn 978-1-4244-0922-8
dc.identifier.issn 1082-3654
dc.description Proceeding of: 2007 IEEE Nuclear Science Symposium Conference Record (NSS'07), Honolulu, Hawaii, USA, Oct. 27 - Nov. 3, 2007
dc.description.abstract The potential of PET imaging for pre-clinical studies will be fully realized only if repeatable, reliable and accurate quantitative analysis can be performed. The characteristic blurring of PET images due to positron range and non co-linearity, as well as random, pile-up and scatter contributions, that may be significant for fully 3D PET acquisitions of small animal, make it difficult their quantitative analysis. In this work specific activity versus specific counts in the image calibration curves for 3D-OSEM reconstructions from a commercially available small animal PET scanner are determined. Both linear and non-linear calibration curves are compared and the effect of corrections for random and scatter contributions are studied. To assess the improvement in the calibration procedure when scatter and random corrections are considered, actual data from a rat tumor pre- and postcancer therapy are analyzed. The results show that correcting for random and scatter corrections can increase the sensitivity of PET images to changes in the biological response of tumors by more than 15%, compared to uncorrected reconstructions.
dc.description.sponsorship This work has been partially funded by projects TEC2004-07052-C02 of Ministerio de Educación y Ciencia and CD-TEAM, program CENIT, Ministerio de Industria, Spain. Part of the computations of this work were done at the '`High capacity cluster for physical techniques'' of the Faculty for Physical Sciences of the UCM, funded in part by the UE under the FEDER program and in part by the UCM.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Influence of random, pile-up and scatter corrections in the quantification properties of small animal PET scanners
dc.type bookPart
dc.type conferenceObject
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2007.4436985
dc.rights.accessRights openAccess
dc.relation.eventdate October 27 - November 3, 2007
dc.relation.eventplace Honolulu, Hawaii, USA
dc.relation.eventtitle 2007 IEEE Nuclear Science Symposium Conference Record (NSS '07)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 3964
dc.identifier.publicationlastpage 3968
dc.identifier.publicationtitle 2007 IEEE Nuclear Science Symposium Conference Record
dc.identifier.publicationvolume 5
 Find Full text

Files in this item

*Click on file's image for preview. (Embargoed files's preview is not supported)

This item appears in the following Collection(s)

Show simple item record