Fully 4D reconstruction of dynamic SPECT images based on the estimation of spatiotemporal basis coefficients directly from projection measurements

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dc.contributor.author Abella García, Mónica
dc.contributor.author Reutter, Bryan W.
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Gullberg, Grant T.
dc.date.accessioned 2011-09-29T14:07:41Z
dc.date.available 2011-09-29T14:07:41Z
dc.date.issued 2008-10
dc.identifier.bibliographicCitation 2008 IEEE Nuclear Science Symposium Conference Record, Oct. 2008, p. 4604 - 4607
dc.identifier.isbn 978-1-4244-2714-7
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12212
dc.description Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008
dc.description.abstract Quantitative kinetic analysis of dynamic cardiac SPECT data provides unique information that can enable improved discrimination between healthy and diseased tissue, compared to static imaging. Conventional kinetic parameter estimation is based on the reconstruction of a dynamic sequence of 3D images from complete projections and the fitting of the compartmental kinetic models to time-activity curves generated by overlaying regions of interest on the reconstructed sequence. The problem with this approach is that, due to the gantry motion involved and the changes in the distribution of radiopharmaceutical during the acquisition, the projection data at different angles come from ditTerent tracer distributions resulting in inconsistent projections. Images reconstructed from these inconsistent projections can contain artifacts that lead to bias in the estimated kinetic parameters. In this work we present a fully 4D reconstruction algorithm for dynamic SPECT in a parallel ray geometry. The method is based on modeling the spatial and temporal distribution of the radiotracer inside the field of view with spatial tri-linear B-spline and 4 piecewise quadratic temporal B-spline basis functions The algorithm was tested on a dynamic 99mTc-teboroxime cardiac SPECT/CT canine study.
dc.description.sponsorship This work is partially funded by the CD-TEAM Project, CENIT Program, Spanish Ministerio de Industria, with grants from the Ministerio de Educaci6n y Ciencia, projects TEC200764731 and TEC2008-06715-C02-01, and grants ROIEBOO121 and ROIHL71253 from the National Institutes of Health (NIH) and the U.S. Department of Energy under Contract No. DE-AC03-76SFOOO98.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Fully 4D reconstruction of dynamic SPECT images based on the estimation of spatiotemporal basis coefficients directly from projection measurements
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2008.4774382
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2008.4774382
dc.rights.accessRights openAccess
dc.relation.eventdate October 19-25, 2008
dc.relation.eventplace Dresden, Germany
dc.relation.eventtitle 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 4604
dc.identifier.publicationlastpage 4607
dc.identifier.publicationtitle 2008 IEEE Nuclear Science Symposium Conference Record
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