PET/CT alignment for small animal scanners based on capillary detection

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dc.contributor.author Rodríguez Ruano, Alexia
dc.contributor.author Pascau González-Garzón, Javier
dc.contributor.author Chamorro Servent, Judit
dc.contributor.author Sisniega, Alejandro
dc.contributor.author García Vázquez, Verónica
dc.contributor.author Udías, Ángel
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Desco Menéndez, Manuel
dc.date.accessioned 2011-09-29T10:50:17Z
dc.date.available 2011-09-29T10:50:17Z
dc.date.issued 2008-10
dc.identifier.bibliographicCitation 2008 IEEE Nuclear Science Symposium Conference Record, oct. 2008, p. 3832-3835
dc.identifier.isbn 978-1-4244-2714-7
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12204
dc.description Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008
dc.description.abstract Small animal PETICT devices provide anatomical and molecular imaging at the same time, enabling the joint visualization and analysis of both modalities. An accurate PET/CT alignment is required to correctly interpret these studies. A proper calibration procedure is essential for small animal imaging, since resolution is much higher than in human devices. This work presents an alignment phantom and a method that enable a reliable and replicable measurement of the geometrical relationship between PET and CT modules. The phantom can be built with laboratory materials, and is used to estimate the rigid spatial transformation that aligns both modalities. consists of three glass capillaries located in noncoplanar triangular geometry and filled with FDG, so they are easily identified in both modalities. The method is based on automatic line detection and localization of the corresponding points between the lines on both modalities, which allows calculating the rigid alignment parameters. Different geometric configurations of the phantom (i.e. different angles and distances between capillaries) were tested to assess the repeatability of the calculations. To measure the alignment precision achieved, we attached two additional sodium point sources to the phantom, which were neglected in the registration process. Our results show that the accuracy of the alignment estimation, measured as average misalignment of the Na sources, is below half the PET resolution. The alternative settings for the phantom layout did not affect this result, indicating the low dependency of the alignment calculated with the actual phantom layout. Our approach allows measuring the PETICT transformation parameters using an in-house built phantom and with low computational effort and high accuracy, demonstrating that the proposed phantom is suitable for alignment calibration of dual modality systems on a real environment.
dc.description.sponsorship This work is partially funded by the CD-TEAM Project, CENIT Program, Spanish Ministerio de Industria, and with grants from the Ministerio de Educaci6n y Ciencia, projects TEC2007-64731 and TEC2008-06715-C02-01
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title PET/CT alignment for small animal scanners based on capillary detection
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2008.4774117
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2008.4774117
dc.rights.accessRights openAccess
dc.relation.eventdate October 19-25, 2008
dc.relation.eventplace Dresden, Germany
dc.relation.eventtitle 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 3832
dc.identifier.publicationlastpage 3835
dc.identifier.publicationtitle 2008 IEEE Nuclear Science Symposium Conference Record
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