Use of IBASPM atlas-based automatic segmentation toolbox in pathological brains: effect of template selection

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Show simple item record García Vázquez, Verónica Reig, Santiago Janssen, Joost Pascau González-Garzón, Javier Rodríguez Ruano, Alexia Udías, Ángel Chamorro Servent, Judit Vaquero López, Juan José Desco Menéndez, Manuel 2011-09-28T15:57:57Z 2011-09-28T15:57:57Z 2008-10
dc.identifier.bibliographicCitation 2008 IEEE Nuclear Science Symposium Conference Record, oct. 2008, p. 4270-4272
dc.identifier.isbn 978-1-4244-2714-7
dc.identifier.issn 1082-3654
dc.description Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 Oct. 2008
dc.description.abstract IBASPM software is an atlas-based method for automatic segmentation of brain structures, available as a freeware toolbox for the SPM package. To test the influence of the atlas when segmenting normal and pathologic brains, manual segmentation of the caudate nucleus head was compared to automatic segmentations using four different atlases: the default MNI AAL atlas; a customized atlas created from a combined sample of patients (n=20) and controls (n=18); and a customized atlas obtained separately for each group. Maximum average ratio of overlapping voxels (dice overlap) between manual and automatic segmentation was 71 o~ for controls and 52% for patients. In both groups, overlap ratios were better when using the customized atlases, instead of the standard MNI AAL atlas. Accuracy of the method was biased between left and right hemispheres, and also between groups, individual variability being higher in patients than in controls. Volumetric measurements using the customized atlases were also more accurate than using the MNI AAL atlas. Volume data were closer to manual segmentation values than dice overlap ratio (average differences ranging from 22.7°~ for MNI AAL atlas to 10.1 for customized atlas of patients and controls combined). Results suggests a low overaU performance of IBASPM as an automatic segmentation method for the head of the caudate nucleus. Because of the biases observed, the use of this method for analyzing caudate nucleus in patients presenting anatomical abnormalities should be cautiously carried out.
dc.description.sponsorship This work is partially funded by the following projects: CD-TEAM Project, CENIT Program (Spanish Ministerio de Industria)~ FIS PI052271 (Spanish Ministerio de Sanidad y Consumo)~ and Fundación Mutua Madrilena
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Use of IBASPM atlas-based automatic segmentation toolbox in pathological brains: effect of template selection
dc.type bookPart
dc.type conferenceObject
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2008.4774225
dc.rights.accessRights openAccess
dc.relation.eventdate October 19-25, 2008
dc.relation.eventplace Dresden, Germany
dc.relation.eventtitle 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 4270
dc.identifier.publicationlastpage 4272
dc.identifier.publicationtitle 2008 IEEE Nuclear Science Symposium Conference Record
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