Validation of a restrospective respiratory gating method for small-animal CT scanners

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dc.contributor.author Chavarrías, Cristina
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Sisniega, Alejandro
dc.contributor.author Rodríguez Ruano, Alexia
dc.contributor.author Soto Montenegro, M. L.
dc.contributor.author Desco Menéndez, Manuel
dc.date.accessioned 2011-09-28T15:13:19Z
dc.date.available 2011-09-28T15:13:19Z
dc.date.issued 2008-10
dc.identifier.bibliographicCitation 2008 IEEE Nuclear Science Symposium Conference Record, oct. 2008, p. 4303 - 4305
dc.identifier.isbn 978-1-4244-2714-7
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12200
dc.description Proceeding of: 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08), Dresden, Germany, 19-25 October 2008
dc.description.abstract We propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections of small-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, subtraction of their average image from each individual frame produces a set of difference images. The respiratory signals were extracted by analyzing the shape of the histogram of these difference images: we calculated the first four central and non-central moments. However, only odd-order moments produced the desired breathing signal, as the even-order moments lacked information about the phase. Each of these curves was compared to a reference signal recorded by means of a pneumatic pillow. Given the similar correlation coefficients yielded by all of them, we selected the mean to implement our retrospective protocol. Respiratory phase bins were separated, reconstructed independently and included in a dynamic sequence, suitable for cine playback. We validated our method in 5 adult rat studies by comparing profiles drawn across the diaphragm dome, with and without retrospective respiratory gating. Results showed a sharper transition in the gated reconstruction, with an average slope improvement of 60.7%.
dc.description.sponsorship This project was supported by the CENIT Programme (Ministerio de Industria), CIBER CB07/09/0031 and RETICRECAVA (Ministerio de Sanidad y Consumo), and TEC2007-64731 TCM (Ministerio de Educaci6n y Ciencia).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Validation of a restrospective respiratory gating method for small-animal CT scanners
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2008.4774235
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2008.4774235
dc.rights.accessRights openAccess
dc.relation.eventdate October 19-25, 2008
dc.relation.eventplace Dresden, Germany
dc.relation.eventtitle 2008 IEEE Nuclear Science Symposium Conference Record (NSS '08)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 4303
dc.identifier.publicationlastpage 4305
dc.identifier.publicationtitle 2008 IEEE Nuclear Science Symposium Conference Record
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