FDOT reconstruction and setting optimization using singular value analysis with automatic thresholding

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dc.contributor.author Chamorro Servent, Judit
dc.contributor.author Aguirre, Juan
dc.contributor.author Ripoll Lorenzo, Jorge
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Desco Menéndez, Manuel
dc.date.accessioned 2011-09-27T14:31:57Z
dc.date.available 2011-09-27T14:31:57Z
dc.date.issued 2009-10
dc.identifier.bibliographicCitation 2009 IEEE Nuclear Science Symposium Conference Record, Oct. 2009, p. 2827-2829
dc.identifier.isbn 978-1-4244-3961-4
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12197
dc.description 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC), Orlando, Florida, 25-31 October 2009
dc.description.abstract Fluorescence Enhanced Diffuse Optical Tomography (FDOT) retrieves 3D distributions of fluorophore concentration in small animals, non-invasively and in vivo. The FDOT problem can be formulated as a system of equations, d=Wf, where W is a weight matrix that couples the measurements (d) to the unknown spatial distribution (f) of the fluorophore concentration (forward problem). The Singular Value Decomposition (SVD) of W has been previously employed to solve the inverse problem (image reconstruction) and to study the imaging performance of FDOT. To achieve good image quality it is necessary to determine the number of useful singular values to retain. We use an automatic method that analytically calculates a threshold to select the significant singular values for SVD reconstruction of FDOT experiments previously validity in our laboratory. Afterwards, this work appraises the effect of different settings of the acquisition parameters (distribution of mesh points, density of sources and detectors) of a parallel-plate noncontact FDOT, in order to achieve the best possible imaging performance, i.e., minimum number of singular values of W, maximum information content in acquired measurements and minimum computational cost. We conclude that the use of a mesh with lower density in the direction perpendicular to the plates achieves better performance than the usual isotropic mesh points distribution. Any increase in the number of mesh points, sources and detectors at distances shorter than the photon mean free path leads to slight improvements in image quality while increasing computational burden.
dc.description.sponsorship This work is supported in part by Fundacion Caja Navarra (#12180), Ministerio de Ciencia e Innovacion (TEC2008-06715 and TEC2007-64731) and EU-FP7 project FMTXCT-201792.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.subject.other Fluorescence
dc.subject.other Diffuse
dc.subject.other Optical
dc.subject.other Tomography
dc.subject.other Regularization
dc.subject.other U-curve
dc.subject.other Optimization
dc.subject.other SVD
dc.subject.other Singular
dc.subject.other Value
dc.subject.other Analysis
dc.title FDOT reconstruction and setting optimization using singular value analysis with automatic thresholding
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2009.5401647
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2009.5401647
dc.rights.accessRights openAccess
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201792
dc.relation.projectID Gobierno de España. TEC2008-06715
dc.relation.projectID Gobierno de España. TEC2007-64731
dc.relation.eventdate October 25-31, 2009
dc.relation.eventplace Orlando, Florida
dc.relation.eventtitle 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC)
dc.relation.eventtype proceeding
dc.identifier.publicationfirstpage 2827
dc.identifier.publicationlastpage 2829
dc.identifier.publicationtitle 2009 IEEE Nuclear Science Symposium Conference Record
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