Assessment of a new CT system for small animals

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dc.contributor.author Redondo, Santiago
dc.contributor.author Vaquero López, Juan José
dc.contributor.author Abella García, Mónica
dc.contributor.author Tapias, Gustavo
dc.contributor.author Udías, Ángel
dc.contributor.author Desco Menéndez, Manuel
dc.contributor.author Lage Negro, Eduardo
dc.date.accessioned 2011-09-22T12:14:14Z
dc.date.available 2011-09-22T12:14:14Z
dc.date.issued 2006-10
dc.identifier.bibliographicCitation 2006 IEEE Nuclear Science Symposium Conference Record, 2006, vol. 6, p. 3553 - 3556
dc.identifier.isbn 1-4244-0560-2
dc.identifier.issn 1082-3654
dc.identifier.uri http://hdl.handle.net/10016/12148
dc.description Proceeding of: 2006 IEEE Nuclear Science Symposium Conference Record, San Diego, CA, Oct. 29 - Nov. 1, 2006
dc.description.abstract We have developed an X-ray cone beam tomograph for in vivo small-animal imaging using a flat panel detector (CMOS technology with a columnar CsI scintillator plate) and a microfocus X-ray source in a geometric configuration with 1.6 magnification and 7.5 cm2 field of view. This work presents an initial characterization of this new system. We measured the detector modulation transfer function (MTF), detector stability, system resolution, the quality of the reconstructed tomographic images and radiated dose. The system resolution was measured following the standard test method ASTM E1696-95. For image quality evaluation, we assessed signal to noise ratio (SNR) and contrast to noise ratio (CNR) with respect to radiated dose. Measurements have been performed on Hounsfield-calibrated images of quantitative phantoms. Effective dose studies have been performed introducing TLD dosimeters in representative organs (ICRU criteria) of euthanized laboratory rats for different imaging protocols. Noise measurements indicate that 50 HU can be achieved at a dose of 10 cGy. Effective dose in standard research methods is below 200 mSv, confirming that the system is appropriate for in vivo imaging. Maximum spatial resolution achieved is better than 50 microns. Experimental results on image quality phantoms as well as on in-vivo studies show that the use of CMOS flat panel is a good choice in terms of quality with respect to radiated dose.
dc.description.sponsorship This work was supported in part by the Spanish Ministerio de Educación y Ciencia under Grant No. TEC2004-07052-C02, la Comunidad de Madrid Grant No. GR/SAL/024104 CD Team,and the CENIT program of the Spanish Ministerio de Industria.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher IEEE
dc.rights © IEEE
dc.title Assessment of a new CT system for small animals
dc.type bookPart
dc.type conferenceObject
dc.relation.publisherversion http://dx.doi.org/10.1109/NSSMIC.2006.356556
dc.subject.eciencia Biología y Biomedicina
dc.identifier.doi 10.1109/NSSMIC.2006.356556
dc.rights.accessRights openAccess
dc.relation.eventdate Oct. 29 - Nov. 1, 2006
dc.relation.eventplace San Diego, CA
dc.relation.eventtitle 2006 IEEE Nuclear Science Symposium Conference Record
dc.identifier.publicationfirstpage 3553
dc.identifier.publicationlastpage 3556
dc.identifier.publicationtitle 2006 IEEE Nuclear Science Symposium Conference Record
dc.identifier.publicationvolume 6
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