Statistical parametric mapping (SPM) is an analysis technique long been used in clinical research to detect subtle activity changes in brain; it is an excellent exploratory tool as it does not require a priori assumptions about the expected brain region activaStatistical parametric mapping (SPM) is an analysis technique long been used in clinical research to detect subtle activity changes in brain; it is an excellent exploratory tool as it does not require a priori assumptions about the expected brain region activations.
Research in animal imaging may also take benefit from this technique, if properly adapted to the new scenario. This is the case of brain activation studies in murine models using PET tracers and dedicated imaging devices. This work proposes the use of an SPM methodology adapted to the analysis of 2-deoxy-2-[18F] fluoro-D-Glucose (FDG) positron emission tomography (PET) scans of rat brains. Advantages over conventional region of interest (ROI) based analysis were assessed in an experiment addressing the detection of brain activation in of rats which underwent three different visual stimulation paradigms[+][-]
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[Abstract] AMI International Conference 2003, September 21 - 27, Madrid, Spain: High Resolution Molecular Imaging: from Basic Science to Clinical Applications
