Atlas-based automated positioning of outer volume suppression slices in short-TE 3D MR spectroscopic imaging of the human brain

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dc.contributor.author Yung, Kaung-Ti
dc.contributor.author Zheng, Weili
dc.contributor.author Zhao, Chenguang
dc.contributor.author Van der Kouwe, André
dc.contributor.author Martínez-Ramón, Manel
dc.contributor.author Posse, Stefan
dc.date.accessioned 2011-07-05T14:02:57Z
dc.date.available 2011-07-05T14:02:57Z
dc.date.issued 2011-04-05
dc.identifier.bibliographicCitation Magnetic Resonance in Medicine, (2011), 66(4), 911-922.
dc.identifier.issn 1522-2594
dc.identifier.uri http://hdl.handle.net/10016/11696
dc.description.abstract Spatial suppression of peripheral lipid-containing regions in volumetric MR spectroscopic imaging (MRSI) of the human brain requires placing large numbers of outer volume suppression (OVS) slices, which is time consuming, prone to operator error and may introduce subject-dependent variability in volume coverage. We developed a novel, computationally efficient atlas-based approach for automated positioning of up to 16 OVS slices and the MRSI slab. Standardized positions in MNI atlas space were established offline using a recently developed iterative optimization procedure. During the scanning session, positions in subject space were computed using affine transformation of standardized positions in MNI space. This atlas-based approach was characterized offline using MPRAGE data collected in 11 subjects. The method was further validated in 14 subjects on a clinical 3T scanner using 3D short TE (15-20ms) Proton-Echo-Planar-Spectroscopic-Imaging (PEPSI) in upper cerebrum. Comparison of manual and automatic placement using 8 OVS slices demonstrated consistent MRSI volume selection and comparable spectral quality with similar degree of lipid suppression and number of usable voxels. Automated positioning of 16 OVS slices enabled larger volume coverage, while maintaining similar spectral quality and lipid suppression. Atlas-based automatic prescription of short TE MRSI is expected to be advantageous for longitudinal and cross sectional studies
dc.description.sponsorship This work was supported in part by the MIND Research Network (DOE Grant No. DE-FG02-99ER62764) and the University of New Mexico School of Medicine Brain and Behavioral Illness Signature Program.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley-Liss
dc.rights © Wiley-Liss
dc.subject.other Outer Volume Suppression
dc.subject.other MR spectroscopic imaging
dc.subject.other Brain imaging
dc.title Atlas-based automated positioning of outer volume suppression slices in short-TE 3D MR spectroscopic imaging of the human brain
dc.type article
dc.description.status Publicado
dc.relation.publisherversion http://dx.doi.org/10.1002/mrm.22887
dc.subject.eciencia Telecomunicaciones
dc.identifier.doi 10.1002/mrm.22887
dc.rights.accessRights openAccess
dc.type.version submittedVersion
dc.identifier.publicationfirstpage 911
dc.identifier.publicationissue 4
dc.identifier.publicationlastpage 922
dc.identifier.publicationtitle Magnetic Resonance in Medicine
dc.identifier.publicationvolume 66
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