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Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues

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dc.affiliation.dptoUC3M. Departamento de Bioingenieríaes
dc.affiliation.grupoinvUC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Groupes
dc.contributor.authorHoekzema, Elseline
dc.contributor.authorTamnes, Christian K.
dc.contributor.authorBerns, Puck
dc.contributor.authorBarba-Müller, Erika
dc.contributor.authorPozzobon, Cristina
dc.contributor.authorPicado, Marisol
dc.contributor.authorLucco, Florencio
dc.contributor.authorMartínez García, Magdalena Teresa
dc.contributor.authorDesco Menéndez, Manuel
dc.contributor.authorBallesteros, Agustín
dc.contributor.authorCrone, Eveline A.
dc.contributor.authorVilarroya, Óscar
dc.contributor.authorCarmona Cañabate, Susana
dc.date.accessioned2023-07-06T11:52:33Z
dc.date.available2023-07-06T11:52:33Z
dc.date.issued2020-02-01
dc.description.abstractIn mothers, offspring cues are associated with a powerful reinforcing value that motivates maternal care. Animal studies show that this is mediated by dopamine release into the nucleus accumbens, a core component of the brain's reward system located in the ventral striatum (VStr). The VStr is also known to respond to infant signals in human mothers. However, it is unknown whether pregnancy modifies the anatomy or functionality of this structure, and whether such modifications underlie its strong reactivity to offspring cues. Therefore, we analyzed structural and functional neuroimaging data from a unique pre-conception prospective cohort study involving first-time mothers investigated before and after their pregnancy as well as noneiparous control women scanned at similar time intervals. First, we delineated the anatomy of the VStr in each subject's neuroanatomical space and examined whether there are volumetric changes in this structure across sessions. Then, we tested if these changes could predict the mothers' brain responses to visual stimuli of their infants. We found decreases in the right VStr and a trend for left VStr reductions in the women who were pregnant between sessions compared to the women who were not. Furthermore, VStr volume reductions across pregnancy were associated with infant-related VStr responses in the postpartum period, with stronger volume decreases predicting stronger functional activation to offspring cues. These findings provide the first indications that the transition to motherhood renders anatomical adaptations in the VStr that promote the strong responsiveness of a mother's reward circuit to cues of her infant.en
dc.description.sponsorshipThis project was supported by an Innovational Research Incentives Scheme grant (Veni, 451-14-036 ) by the Netherlands Organisation for Scientific Research (NWO), the Netherlands , and a NARSAD Grant from the Brain & Behavior Research Foundation, U.S.A. (grant number 25312 ) awarded to Elseline Hoekzema, as well as a Ministerio de Ciencia, Innovación y Universidades (Spain) Instituto de Salud Carlos III project ( PI17/00064 ) and a Miguel Servet Type I research contract CP16/00096 awarded to Susanna Carmona. In addition, Magdalena Martínez-García was funded by a Ministerio de Ciencia, Innovación y Universidades (Spain), Instituto de Salud Carlos III ( PFIS contract FI18/00255 ) grant.en
dc.format.extent9es
dc.identifier.bibliographicCitationHoekzema, E., Tamnes, C. K., Berns, P., Barba-Müller, E., Pozzobon, C., Picado, M., Lucco, F., Martínez-García, M., Desco, M., Ballesteros, A., Crone, E. A., Vilarroya, O., & Carmona, S. (2020). Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues. Psychoneuroendocrinology, 112, 104507.en
dc.identifier.doihttps://doi.org/10.1016/j.psyneuen.2019.104507
dc.identifier.issn0306-4530
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissue104507es
dc.identifier.publicationlastpage9es
dc.identifier.publicationtitlePSYCHONEUROENDOCRINOLOGYen
dc.identifier.publicationvolume112es
dc.identifier.urihttps://hdl.handle.net/10016/37773
dc.identifier.uxxiAR/0000025553
dc.language.isoengen
dc.publisherElsevieren
dc.relation.projectIDGobierno de España. PI17/00064es
dc.relation.projectIDGobierno de España. CP16/00096es
dc.relation.projectIDGobierno de España. FI18/00255es
dc.rights© 2019 The Authors. Published by Elsevier Ltd.en
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España*
dc.rights.accessRightsopen accessen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subject.ecienciaBiología y Biomedicinaes
dc.subject.ecienciaElectrónicaes
dc.subject.ecienciaIngeniería Mecánicaes
dc.subject.otherAdulten
dc.subject.otherCuesen
dc.subject.otherHumansen
dc.subject.otherNeuroimagingen
dc.subject.otherParityen
dc.subject.otherPregnancyen
dc.subject.otherRewarden
dc.subject.otherArticleen
dc.subject.otherConceptionen
dc.subject.otherFemaleen
dc.subject.otherHumanen
dc.subject.otherInfanten
dc.subject.otherMotheren
dc.subject.otherNulliparaen
dc.subject.otherPregnancyen
dc.subject.otherProgenyen
dc.subject.otherPuerperiumen
dc.subject.otherRewarden
dc.subject.otherAssociationen
dc.subject.otherNeuroimagingen
dc.subject.otherParityen
dc.subject.otherPhysiologyen
dc.subject.otherPregnancyen
dc.subject.otherVentral Striatumen
dc.subject.otherFacial recognitionen
dc.subject.otherMagnetic resonance imagingen
dc.subject.otherMaternal behavioren
dc.subject.otherPostpartum perioden
dc.subject.otherProspective studiesen
dc.subject.otherVentral striatumen
dc.subject.otherCohort analysisen
dc.subject.otherControlled studyen
dc.subject.otherFunctional neuroimagingen
dc.subject.otherHuman experimenten
dc.subject.otherNuclear magnetic resonance imagingen
dc.subject.otherNucleus accumbensen
dc.subject.otherProspective studyen
dc.subject.otherAnatomy and histologyen
dc.subject.otherDiagnostic imagingen
dc.subject.otherFacial Recognitionen
dc.subject.otherMaternal behavioren
dc.subject.otherNuclear magnetic resonance imagingen
dc.titleBecoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cuesen
dc.typeresearch article*
dc.type.hasVersionVoR*
dspace.entity.typePublication
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