Publication: Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues
dc.affiliation.dpto | UC3M. Departamento de Bioingeniería | es |
dc.affiliation.grupoinv | UC3M. Grupo de Investigación: Biomedical Imaging and Instrumentation Group | es |
dc.contributor.author | Hoekzema, Elseline | |
dc.contributor.author | Tamnes, Christian K. | |
dc.contributor.author | Berns, Puck | |
dc.contributor.author | Barba-Müller, Erika | |
dc.contributor.author | Pozzobon, Cristina | |
dc.contributor.author | Picado, Marisol | |
dc.contributor.author | Lucco, Florencio | |
dc.contributor.author | Martínez García, Magdalena Teresa | |
dc.contributor.author | Desco Menéndez, Manuel | |
dc.contributor.author | Ballesteros, Agustín | |
dc.contributor.author | Crone, Eveline A. | |
dc.contributor.author | Vilarroya, Óscar | |
dc.contributor.author | Carmona Cañabate, Susana | |
dc.date.accessioned | 2023-07-06T11:52:33Z | |
dc.date.available | 2023-07-06T11:52:33Z | |
dc.date.issued | 2020-02-01 | |
dc.description.abstract | In mothers, offspring cues are associated with a powerful reinforcing value that motivates maternal care. Animal studies show that this is mediated by dopamine release into the nucleus accumbens, a core component of the brain's reward system located in the ventral striatum (VStr). The VStr is also known to respond to infant signals in human mothers. However, it is unknown whether pregnancy modifies the anatomy or functionality of this structure, and whether such modifications underlie its strong reactivity to offspring cues. Therefore, we analyzed structural and functional neuroimaging data from a unique pre-conception prospective cohort study involving first-time mothers investigated before and after their pregnancy as well as noneiparous control women scanned at similar time intervals. First, we delineated the anatomy of the VStr in each subject's neuroanatomical space and examined whether there are volumetric changes in this structure across sessions. Then, we tested if these changes could predict the mothers' brain responses to visual stimuli of their infants. We found decreases in the right VStr and a trend for left VStr reductions in the women who were pregnant between sessions compared to the women who were not. Furthermore, VStr volume reductions across pregnancy were associated with infant-related VStr responses in the postpartum period, with stronger volume decreases predicting stronger functional activation to offspring cues. These findings provide the first indications that the transition to motherhood renders anatomical adaptations in the VStr that promote the strong responsiveness of a mother's reward circuit to cues of her infant. | en |
dc.description.sponsorship | This project was supported by an Innovational Research Incentives Scheme grant (Veni, 451-14-036 ) by the Netherlands Organisation for Scientific Research (NWO), the Netherlands , and a NARSAD Grant from the Brain & Behavior Research Foundation, U.S.A. (grant number 25312 ) awarded to Elseline Hoekzema, as well as a Ministerio de Ciencia, Innovación y Universidades (Spain) Instituto de Salud Carlos III project ( PI17/00064 ) and a Miguel Servet Type I research contract CP16/00096 awarded to Susanna Carmona. In addition, Magdalena Martínez-García was funded by a Ministerio de Ciencia, Innovación y Universidades (Spain), Instituto de Salud Carlos III ( PFIS contract FI18/00255 ) grant. | en |
dc.format.extent | 9 | es |
dc.identifier.bibliographicCitation | Hoekzema, E., Tamnes, C. K., Berns, P., Barba-Müller, E., Pozzobon, C., Picado, M., Lucco, F., Martínez-García, M., Desco, M., Ballesteros, A., Crone, E. A., Vilarroya, O., & Carmona, S. (2020). Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues. Psychoneuroendocrinology, 112, 104507. | en |
dc.identifier.doi | https://doi.org/10.1016/j.psyneuen.2019.104507 | |
dc.identifier.issn | 0306-4530 | |
dc.identifier.publicationfirstpage | 1 | es |
dc.identifier.publicationissue | 104507 | es |
dc.identifier.publicationlastpage | 9 | es |
dc.identifier.publicationtitle | PSYCHONEUROENDOCRINOLOGY | en |
dc.identifier.publicationvolume | 112 | es |
dc.identifier.uri | https://hdl.handle.net/10016/37773 | |
dc.identifier.uxxi | AR/0000025553 | |
dc.language.iso | eng | en |
dc.publisher | Elsevier | en |
dc.relation.projectID | Gobierno de España. PI17/00064 | es |
dc.relation.projectID | Gobierno de España. CP16/00096 | es |
dc.relation.projectID | Gobierno de España. FI18/00255 | es |
dc.rights | © 2019 The Authors. Published by Elsevier Ltd. | en |
dc.rights | Atribución-NoComercial-SinDerivadas 3.0 España | * |
dc.rights.accessRights | open access | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject.eciencia | Biología y Biomedicina | es |
dc.subject.eciencia | Electrónica | es |
dc.subject.eciencia | Ingeniería Mecánica | es |
dc.subject.other | Adult | en |
dc.subject.other | Cues | en |
dc.subject.other | Humans | en |
dc.subject.other | Neuroimaging | en |
dc.subject.other | Parity | en |
dc.subject.other | Pregnancy | en |
dc.subject.other | Reward | en |
dc.subject.other | Article | en |
dc.subject.other | Conception | en |
dc.subject.other | Female | en |
dc.subject.other | Human | en |
dc.subject.other | Infant | en |
dc.subject.other | Mother | en |
dc.subject.other | Nullipara | en |
dc.subject.other | Pregnancy | en |
dc.subject.other | Progeny | en |
dc.subject.other | Puerperium | en |
dc.subject.other | Reward | en |
dc.subject.other | Association | en |
dc.subject.other | Neuroimaging | en |
dc.subject.other | Parity | en |
dc.subject.other | Physiology | en |
dc.subject.other | Pregnancy | en |
dc.subject.other | Ventral Striatum | en |
dc.subject.other | Facial recognition | en |
dc.subject.other | Magnetic resonance imaging | en |
dc.subject.other | Maternal behavior | en |
dc.subject.other | Postpartum period | en |
dc.subject.other | Prospective studies | en |
dc.subject.other | Ventral striatum | en |
dc.subject.other | Cohort analysis | en |
dc.subject.other | Controlled study | en |
dc.subject.other | Functional neuroimaging | en |
dc.subject.other | Human experiment | en |
dc.subject.other | Nuclear magnetic resonance imaging | en |
dc.subject.other | Nucleus accumbens | en |
dc.subject.other | Prospective study | en |
dc.subject.other | Anatomy and histology | en |
dc.subject.other | Diagnostic imaging | en |
dc.subject.other | Facial Recognition | en |
dc.subject.other | Maternal behavior | en |
dc.subject.other | Nuclear magnetic resonance imaging | en |
dc.title | Becoming a mother entails anatomical changes in the ventral striatum of the human brain that facilitate its responsiveness to offspring cues | en |
dc.type | research article | * |
dc.type.hasVersion | VoR | * |
dspace.entity.type | Publication |
Files
Original bundle
1 - 1 of 1